在巴西蛙Rhodei叶泡蛙皮肤提取物中鉴定出皮吗啡和Hyp6-皮吗啡。
Identification of dermorphin and Hyp6-dermorphin in skin extracts of the Brazilian frog Phyllomedusa rhodei.
作者信息
Montecucchi P C, de Castiglione R, Erspamer V
出版信息
Int J Pept Protein Res. 1981 Mar;17(3):316-21. doi: 10.1111/j.1399-3011.1981.tb01997.x.
Abstract
Methanol extracts of the skin of the Brazilian frog Phyllomedusa rhodei contain approximately equal amounts of dermorphin and its analogue Hyp6-dermorphin, two opiate-like heptapeptides. A unique feature of their sequence is the presence of a D-amino acid residue at position 2. Hyp6-dermorphin possesses a spectrum of central and peripheral bioactivity very similar to that of dermorphin.
摘要
巴西青蛙罗德氏叶泡蛙皮肤的甲醇提取物含有大致等量的皮啡肽及其类似物Hyp6-皮啡肽，这两种都是类阿片七肽。它们序列的一个独特特征是在第2位存在一个D-氨基酸残基。Hyp6-皮啡肽具有一系列与皮啡肽非常相似的中枢和外周生物活性。
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