Nornes H O, Carry M
Brain Res. 1978 Dec 22;159(1):1-6. doi: 10.1016/0006-8993(78)90105-1.
An autoradiographic analysis of the time and sites of origin, and the migration and settling patterns of neurons was made in the spinal cord of the mouse. The neurons originated on days 10--14 of gestation with temporal gradients along the ventrodorsal and rostrocaudal axes. The motor neurons originated on days 10 and 11 of gestation; the neurons in the intermediate gray region originated on days 11--14 of gestation; the neurons of the head of the dorsal horn originated on days 12--14 of gestation. The neurons that originated on days 10 and 11 originated and migrated primarily from the basal plate, and they settled in the adjacent regions of the intermediate zone; those neurons formed on days 12--14 originated and migrated primarily from the alar plate, and it was concluded that these neuroblasts similarly settled in the adjacent regions of the intermediate zone. Extraventricular proliferation, which presumably signaled the initial stages of gliogenesis, was first observed on day 12 of gestation. This study supports the classical idea of the mosaic pattern of neurogenesis in the embryonic spinal cord.
对小鼠脊髓中神经元的起源时间和部位、迁移及定居模式进行了放射自显影分析。神经元起源于妊娠第10 - 14天，沿腹背轴和头尾轴存在时间梯度。运动神经元起源于妊娠第10和11天；中间灰质区域的神经元起源于妊娠第11 - 14天；背角头部的神经元起源于妊娠第12 - 14天。起源于第10和11天的神经元主要从基板起源并迁移，它们定居在中间带的相邻区域；在第12 - 14天形成的那些神经元主要从翼板起源并迁移，得出的结论是这些神经母细胞同样定居在中间带的相邻区域。推测为胶质发生初始阶段的室管膜外增殖在妊娠第12天首次观察到。本研究支持胚胎脊髓神经发生镶嵌模式的经典观点。
