胶原蛋白及胶原蛋白衍生片段对肿瘤细胞具有趋化作用。
Collagen and collagen-derived fragments are chemotactic for tumor cells.
作者信息
Mundy G R, DeMartino S, Rowe D W
出版信息
J Clin Invest. 1981 Oct;68(4):1102-5. doi: 10.1172/jci110334.
Abstract
Organs that are rich in collagen such as liver, lungs, and bone are frequently sites of tumor cell metastasis. In this study, we have found that cultured tumor cells of human and rat origin migrated unidirectionally in response to collagen in vitro. Synthetic di- and tri-peptides that contained amino acid sequences found frequently in the collagen helix caused similar effects. These results are consistent with the hypothesis that collagen or collagen fragments released during connective tissue remodeling may be important in tumor cell metastasis.
摘要
富含胶原蛋白的器官，如肝脏、肺和骨骼，常常是肿瘤细胞转移的部位。在本研究中，我们发现源自人和大鼠的培养肿瘤细胞在体外对胶原蛋白产生单向迁移反应。含有胶原蛋白螺旋中常见氨基酸序列的合成二肽和三肽也产生了类似的效果。这些结果与以下假设一致：在结缔组织重塑过程中释放的胶原蛋白或胶原蛋白片段可能在肿瘤细胞转移中起重要作用。
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本文引用的文献
1
THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO.血清补体在体外白细胞趋化性中的作用
J Exp Med. 1965 Aug 1;122(2):327-46. doi: 10.1084/jem.122.2.327.
2
Partial characterization of a bone-derived chemotactic factor for tumor cells.一种骨源性肿瘤细胞趋化因子的部分特性
Am J Pathol. 1980 Apr;99(1):43-52.
3
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
4
Collagen polymorphism: characterization of molecules with the chain composition (alpha 1 (3)03 in human tissues.胶原蛋白多态性：人体组织中具有链组成（α1(3)03）的分子的特征
Science. 1974 Mar;183(130):1200-1. doi: 10.1126/science.183.4130.1200.
5
Breast tumor cell lines from pleural effusions.来自胸腔积液的乳腺肿瘤细胞系。
J Natl Cancer Inst. 1974 Sep;53(3):661-74. doi: 10.1093/jnci/53.3.661.
6
Collagen-and collagen peptide-induced chemotaxis of human blood monocytes.胶原蛋白及胶原蛋白肽诱导人血单核细胞的趋化作用。
J Exp Med. 1976 Jun 1;143(6):1299-307. doi: 10.1084/jem.143.6.1299.
7
The estimation of two collagens from human dermis by interrupted gel electrophoresis.
Biochem Biophys Res Commun. 1976 Oct 18;72(4):1472-80. doi: 10.1016/s0006-291x(76)80180-5.
8
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J Clin Invest. 1976 Jun;57(6):1498-507. doi: 10.1172/JCI108420.
9
Chemotactic responses of tumor cells to products of resorbing bone.
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