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早期类风湿关节炎的体外淋巴细胞反应

In vitro lymphocyte response in early rheumatoid arthritis.

作者信息

Runge L A

出版信息

J Rheumatol. 1981 May-Jun;8(3):468-75.

PMID:7288764
Abstract

Streptokinase-streptodornase (SK-SD) skin tests and peripheral blood mononuclear stimulation to purified SK-SD delayed skin reactor (DSR) and phytohemagglutinin (PHA) was assessed in 41 patients with rheumatoid arthritis (RA) and 17 controls. Lymphocyte response to DSR correlated directly with the diameter of SK-SD-induced erythema, and PHA stimulation decreased with age. RA patients did not show significant depression by either test or did hyporesponsiveness predict rheumatoid disease activity or prognosis. Six patients without medication demonstrated increased PHA responsiveness and a direct rather than inverse correlation with age.

摘要

对41例类风湿性关节炎（RA）患者和17名对照者进行了链激酶-链道酶（SK-SD）皮肤试验以及对纯化的SK-SD迟发性皮肤反应原（DSR）和植物血凝素（PHA）的外周血单个核细胞刺激评估。淋巴细胞对DSR的反应与SK-SD诱导的红斑直径直接相关，PHA刺激随年龄增长而降低。RA患者在任何一项试验中均未表现出明显的抑制，低反应性也不能预测类风湿疾病的活动或预后。6例未用药的患者表现出PHA反应性增加，且与年龄呈直接而非反向相关。

相似文献

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