下腔静脉结扎后大鼠的口渴：血管紧张素 II 的作用。
Thirst in the rat after ligation of the inferior vena cava: role of angiotensin II.
作者信息
Mann J F, Johnson A K, Rascher W, Genest J, Ganten D
出版信息
Pharmacol Biochem Behav. 1981 Sep;15(3):337-41. doi: 10.1016/0091-3057(81)90259-8.
The role of angiotensin II in thirst states after ligation of the inferior vena cava above (CLA) or below (CLB) the origin of the renal veins as compared to sham operated controls was evaluated 24 hrs after ligation. Water intake was enhanced in CLB rats and even more so in CLA rats. Plasma angiotensin II and urea concentrations and serum osmolality were increased in CLA rats. Plasma sodium concentration and hematocrit were reduced in CLA rats, and hematocrit in CLB rats as well. Water intake in CLA rats was retarded by IV infusions of saralasin. Saralasin infusions in CLA rats resulted in a dramatic increase of plasma angiotensin II concentrations. Ligation of the inferior vena cava induces major changes in body fluid homeostasis, which are more pronounced in CLA than in CLB rats. The increase in water intake in CLA rats appears to be partly mediated by angiotensin II.
与假手术对照组相比，评估了在肾静脉起源上方（CLA）或下方（CLB）结扎下腔静脉后24小时血管紧张素II在口渴状态中的作用。CLB大鼠的水摄入量增加，CLA大鼠更是如此。CLA大鼠的血浆血管紧张素II、尿素浓度和血清渗透压升高。CLA大鼠的血浆钠浓度和血细胞比容降低，CLB大鼠的血细胞比容也降低。CLA大鼠的水摄入量因静脉注射沙拉新而延迟。CLA大鼠注射沙拉新导致血浆血管紧张素II浓度急剧增加。下腔静脉结扎引起体液稳态的重大变化，CLA大鼠比CLB大鼠更明显。CLA大鼠水摄入量的增加似乎部分由血管紧张素II介导。
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