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能引发皮肤反应性移植抗体且不同于兔白细胞抗原(RLA)的兔抗原系统。

System of rabbit antigens which elicit skin-reacting transplantation antibodies and are different from RLA.

作者信息

Kosiński S

出版信息

Arch Immunol Ther Exp (Warsz). 1981;29(3):323-30.

PMID:7294971
Abstract

Relationship between the rabbit histocompatibility RLA system and antigens eliciting skin-reacting transplantation antibodies (SRTA) was studied. The rabbit sera obtained by alloimmunization with skin transplant were investigated in the dye-exclusion cytotoxic test with lymphocytes and in the skin test on a panel of the outbred rabbits. Basing on a pairwise analysis of reactions in the cytotoxic test, some of these sera were classified into three groups of significantly correlated anti-RLA 1, 2, 3 sera. Analysis of reactions in the skin test revealed two groups of significantly correlated sera different from anti-RLA 1, 2, 3, which were designated as anti-SA and anti-SB. All anti-SA and anti-SB sera were also examined in the agglutination test with a panel of red blood cells but none of them was capable of agglutination. Study on tissue distribution of RLA and antigens eliciting SRTA showed that both systems are shared by skin and lymphoid tissue but in the brain tissue only antigens eliciting SRTA were present.

摘要

研究了兔组织相容性RLA系统与引发皮肤反应性移植抗体(SRTA)的抗原之间的关系。用皮肤移植进行同种免疫获得的兔血清,在淋巴细胞的染料排除细胞毒性试验以及一组远交兔的皮肤试验中进行了研究。基于细胞毒性试验中反应的成对分析,其中一些血清被分为三组显著相关的抗RLA 1、2、3血清。皮肤试验中反应的分析揭示了两组与抗RLA 1、2、3不同的显著相关血清,分别被指定为抗SA和抗SB。所有抗SA和抗SB血清也在一组红细胞的凝集试验中进行了检测,但它们均无凝集能力。对RLA和引发SRTA的抗原的组织分布研究表明,这两个系统在皮肤和淋巴组织中都有,但在脑组织中仅存在引发SRTA的抗原。

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Arch Immunol Ther Exp (Warsz). 1981;29(3):323-30.
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