Dalsgaard-Nielsen J, Risbo A, Simmelkjaer P, Gormsen J
Br J Anaesth. 1981 Oct;53(10):1039-42. doi: 10.1093/bja/53.10.1039.
A significant correlation was found between the inhibition produced by 1% halothane with nitrous oxide and oxygen on platelet aggregation in vitro and the increase in bleeding time during anaesthesia with halothane, nitrous oxide and oxygen in 10 patients. It is suggested that halothane in nitrous oxide with oxygen inhibits platelet aggregation in vivo and in vitro. The inhibition is not seen when platelet aggregation is studied in platelet-rich plasma from anaesthetized patients because the agents evaporate during preparation of platelet-rich plasma and during analysis in the aggregometer.
在10例患者中，研究发现1%氟烷与一氧化二氮和氧气混合气体对体外血小板聚集的抑制作用与使用氟烷、一氧化二氮和氧气麻醉期间出血时间的延长之间存在显著相关性。提示氟烷与一氧化二氮和氧气混合气体在体内和体外均能抑制血小板聚集。当在麻醉患者的富血小板血浆中研究血小板聚集时，未观察到这种抑制作用，因为这些药物在富血小板血浆制备过程以及在血小板聚集仪分析过程中会挥发。
