Baer R L, Garcia R L, Partsalidou V, Ackerman A B
J Am Acad Dermatol. 1981 Nov;5(5):561-5. doi: 10.1016/s0190-9622(81)70117-8.
A 73-year-old man had developed a 27 x 60-mm seborrheic keratosis on his trunk. Some months previously, an 18 x 19-mm cauliflower-like area had developed within this seborrheic keratosis. Histologic examination showed a papillated squamous cell carcinoma in situ arising in a seborrheic keratosis. Seborrheic keratoses are the most common cutaneous neoplasms in man. Malignant changes are most unusual but should be suspected in lesions of unusual clinical appearance.
一名73岁男性的躯干上出现了一个27×60毫米的脂溢性角化病。数月前，在这个脂溢性角化病内部出现了一个18×19毫米的菜花状区域。组织学检查显示，在脂溢性角化病基础上发生了原位乳头状鳞状细胞癌。脂溢性角化病是人类最常见的皮肤肿瘤。恶性变化极为罕见，但对于临床表现异常的病变应怀疑有恶变。
