Diep Darlene, Calame Antoanella, Cohen Philip R
Medicine, Burrell College of Osteopathic Medicine, Las Cruces, USA.
Dermatology/Dermatopathology, Compass Dermatopathology, San Diego, USA.
Cureus. 2021 Oct 7;13(10):e18559. doi: 10.7759/cureus.18559. eCollection 2021 Oct.
Seborrheic keratosis is an epithelial-derived benign neoplasm, which presents as a solitary tumor or multiple lesions. It is an acquired skin tumor that is frequently observed in older individuals. Benign neoplasms, as well as premalignant or malignant tumors, can mimic the clinical appearance of a seborrheic keratosis. A man presented with a chronic lesion on his abdomen that had changed in the color and size. The suspected diagnosis was a seborrheic keratosis. However, the microscopic evaluation of a biopsy tissue specimen established a diagnosis of a pigmented squamous cell carcinoma in situ. In addition to squamous cell carcinoma in situ and squamous cell carcinoma, other malignant tumors, premalignant lesions, and benign lesions can mimic a seborrheic keratosis. If a patient presents with a presumptive seborrheic keratosis that has changed in appearance and for which malignancy is also suspected, a biopsy may be helpful for diagnostic clarification to either confirm that the lesion is indeed a seborrheic keratosis or to establish the diagnosis of the lesion that mimics a seborrheic keratosis.
脂溢性角化病是一种上皮来源的良性肿瘤，表现为单个肿瘤或多个损害。它是一种后天性皮肤肿瘤，常见于老年人。良性肿瘤以及癌前或恶性肿瘤都可能模仿脂溢性角化病的临床表现。一名男性患者腹部出现慢性损害，其颜色和大小发生了变化。疑似诊断为脂溢性角化病。然而，活检组织标本的显微镜评估确诊为原位色素性鳞状细胞癌。除了原位鳞状细胞癌和鳞状细胞癌外，其他恶性肿瘤、癌前病变和良性病变也可能模仿脂溢性角化病。如果患者出现外观发生变化且怀疑有恶性可能的疑似脂溢性角化病，活检可能有助于明确诊断，以确认病变确实是脂溢性角化病，或者确诊模仿脂溢性角化病的病变。
