Tsambaos D, Monastirli A, Kapranos N, Georgiou S, Pasmatzi E, Stratigos A, Koutselini H, Berger H
Department of Dermatology, School of Medicine, University of Patras, Greece.
Arch Dermatol Res. 1995;287(6):612-5. doi: 10.1007/BF00374085.
The histological similarities of seborrhoeic keratoses and common warts led to the investigation of the possible occurrence of human papillomavirus DNA (HPV-DNA) in a large number of nongenital seborrhoeic keratoses using the in situ hybridization technique. All specimens derived from normal skin (n = 173) were negative for the applied HPV-DNA probe, whereas the HPV genome was detected in 34 of 173 seborrhoeic keratosis specimens (19.65%). Of 34 HPV-positive specimens, 15 contained types 6/11 and 14 types 31/33/35, and 5 showed no positive reaction to the applied types. These results suggest that a considerable percentage of nongenital seborrhoeic keratoses may be related to an HPV infection.
脂溢性角化病与寻常疣在组织学上的相似性，促使人们运用原位杂交技术，对大量非生殖器部位的脂溢性角化病中人类乳头瘤病毒DNA（HPV-DNA）的可能存在情况展开研究。所有取自正常皮肤的标本（n = 173），在所应用的HPV-DNA探针检测下均呈阴性，而在173例脂溢性角化病标本中，有34例（19.65%）检测到了HPV基因组。在34例HPV阳性标本中，15例含有6/11型，14例含有31/33/35型，还有5例对所应用的类型未呈现阳性反应。这些结果表明，相当比例的非生殖器部位脂溢性角化病可能与HPV感染有关。
