Shirama K, Furuya T, Takeo Y, Shimizu K, Maekawa K
J Endocrinol. 1981 Nov;91(2):305-11. doi: 10.1677/joe.0.0910305.
There are marked sex differences in the Harderian gland of the C3H/He strain of mice. Female (but not male) glands contain large amounts of porphyrin, which are readily visible as solid depositions within the lumina. The histology and porphyrin content of the Harderian gland were examined in intact and in pregnant mice and in mice subjected to combinations of adrenalectomy, gonadectomy and administration of sex steroid hormones. In male mice, castration approximately doubled the amount of porphyrin in the Harderian gland. Castration plus adrenalectomy increased the levels over 30-fold, to levels similar to those found in female mice, although adrenalectomy alone produced no significant effect. Administration of testosterone to the male mice which had been castrated and adrenalectomized prevented the increases while progesterone treatment produced further increases in porphyrins. In intact females, the amount of porphyrin varied with the phase of the oestrous cycle; being lowest during metoestrus and highest during dioestrus. In ovariectomized-adrenalectomized females, the effects of administered sex hormones on the amount of porphyrin in the gland were the same as in males. In pregnant mice, the level was no significantly different from that in intact oestrous animals.
C3H/He品系小鼠的哈德氏腺存在明显的性别差异。雌性（而非雄性）腺体含有大量卟啉，这些卟啉作为管腔内的固体沉积物很容易被看到。对完整小鼠、怀孕小鼠以及接受肾上腺切除术、性腺切除术和给予性类固醇激素组合处理的小鼠的哈德氏腺的组织学和卟啉含量进行了检查。在雄性小鼠中，去势使哈德氏腺中卟啉的含量增加了约一倍。去势加肾上腺切除术使卟啉水平增加了30倍以上，达到与雌性小鼠相似的水平，尽管单独进行肾上腺切除术没有产生显著影响。给已去势和肾上腺切除的雄性小鼠注射睾酮可阻止卟啉增加，而用孕酮处理则使卟啉进一步增加。在完整雌性小鼠中，卟啉的含量随发情周期阶段而变化；在动情后期最低，在间情期最高。在卵巢切除 - 肾上腺切除的雌性小鼠中，给予的性激素对腺体中卟啉含量的影响与雄性小鼠相同。在怀孕小鼠中，卟啉水平与完整发情动物的水平无显著差异。
