糖皮质激素对小鼠血小板活化因子-乙醚毒性的保护作用。
Glucocorticoid protection against PAF-acether toxicity in mice.
作者信息
Myers A, Ramey E, Ramwell P
出版信息
Br J Pharmacol. 1983 Jun;79(2):595-8. doi: 10.1111/j.1476-5381.1983.tb11034.x.
Abstract
Intravenous platelet activating factor (PAF-acether, 10 to 25 micrograms/kg body weight) produced dose-dependent mortality in both male and female mice. Pretreatment with indomethacin (50 mg/kg), verapamil (40 mg/kg) or nifedipine (4 mg/kg) failed to inhibit the lethal effect of 20 micrograms/kg PAF-acether. This suggests that neither arachidonate cyclo-oxygenase products nor availability of extracellular Ca2+ mediate the toxic action. In contrast, pretreatment with 100 mg/kg cortisone acetate (s.c.) daily for four days exerted a highly protective effect, i.e. 100% and 93% survival in males and females, compared to 13% and 7% respectively, in untreated animals. PAF-acether-induced death may be a useful model for the in vivo evaluation of pharmacological agents in anaphylactic shock.
摘要
静脉注射血小板活化因子（PAF-乙醚，10至25微克/千克体重）在雄性和雌性小鼠中均产生剂量依赖性死亡率。用吲哚美辛（50毫克/千克）、维拉帕米（40毫克/千克）或硝苯地平（4毫克/千克）预处理未能抑制20微克/千克PAF-乙醚的致死作用。这表明花生四烯酸环氧化酶产物和细胞外Ca2+的可用性均不介导毒性作用。相比之下，连续四天每天皮下注射100毫克/千克醋酸可的松预处理具有高度保护作用，即雄性和雌性的存活率分别为100%和93%，而未处理动物的存活率分别为13%和7%。PAF-乙醚诱导的死亡可能是体内评估过敏休克中药理剂的有用模型。
相似文献
1
Glucocorticoid protection against PAF-acether toxicity in mice.糖皮质激素对小鼠血小板活化因子-乙醚毒性的保护作用。
Br J Pharmacol. 1983 Jun;79(2):595-8. doi: 10.1111/j.1476-5381.1983.tb11034.x.
2
Paf-acether-induced death in mice: involvement of arachidonate metabolites and beta-adrenoceptors.血小板活化因子诱导的小鼠死亡：花生四烯酸代谢产物和β-肾上腺素能受体的参与
Br J Pharmacol. 1987 Jan;90(1):203-9. doi: 10.1111/j.1476-5381.1987.tb16841.x.
3
The platelet-independent release of thromboxane A2 by Paf-acether from guinea-pig lungs involves mechanisms distinct from those for leukotriene.血小板激活因子从豚鼠肺中释放血栓素A2不依赖血小板，其机制与白三烯不同。
Br J Pharmacol. 1984 Jul;82(3):565-75. doi: 10.1111/j.1476-5381.1984.tb10795.x.
4
Effect of indomethacin and dazoxiben on intravascular platelet aggregation in the anaesthetized rabbit.消炎痛和达唑氧苯对麻醉兔血管内血小板聚集的影响。
Thromb Haemost. 1986 Aug 20;56(1):80-5.
5
Effects of serum albumin, indomethacin and histamine H1-antagonists on Paf-acether-induced inflammatory responses in the skin of experimental animals and man.血清白蛋白、吲哚美辛和组胺H1拮抗剂对实验动物和人类皮肤中血小板活化因子诱导的炎症反应的影响。
Br J Pharmacol. 1985 May;85(1):109-13. doi: 10.1111/j.1476-5381.1985.tb08836.x.
6
Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat.血小板活化因子（PAF-乙醚）在大鼠体内局部炎症与全身血液学效应之间的相互作用。
Eur J Pharmacol. 1987 Apr 29;136(3):353-60. doi: 10.1016/0014-2999(87)90308-6.
7
Partial characterization of the embryo-derived platelet-activating factor in mice.
J Reprod Fertil. 1985 Nov;75(2):375-80. doi: 10.1530/jrf.0.0750375.
8
Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse.
Prostaglandins. 1985 Oct;30(4):545-51. doi: 10.1016/0090-6980(85)90018-8.
9
PAF-acether-induced plasma exudation in rat skin is independent of platelets and neutrophils.血小板活化因子诱导的大鼠皮肤血浆渗出与血小板和中性粒细胞无关。
Microcirc Endothelium Lymphatics. 1984 Feb;1(1):107-22.
10
Platelet-activating factor-acether-induced relaxation of guinea pig airway muscle: role of prostaglandin E2 and the epithelium.血小板激活因子-乙醚诱导的豚鼠气道平滑肌舒张：前列腺素E2和上皮的作用
J Pharmacol Exp Ther. 1987 Oct;243(1):356-63.
引用本文的文献
1
Mast cell modulation of the vascular and lymphatic endothelium.肥大细胞对血管和淋巴管内皮的调节作用。
Blood. 2011 Nov 17;118(20):5383-93. doi: 10.1182/blood-2011-07-358432. Epub 2011 Sep 8.
2
Platelet-activating factor receptor mRNA is localized in eosinophils and epithelial cells in rat small intestine: regulation by dexamethasone and gut flora.血小板活化因子受体mRNA在大鼠小肠的嗜酸性粒细胞和上皮细胞中定位：受地塞米松和肠道菌群调控。
Immunology. 1999 Jul;97(3):447-54. doi: 10.1046/j.1365-2567.1999.00784.x.
3
Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses.5-脂氧合酶激活蛋白（FLAP）在小鼠急性炎症反应中的作用。
J Exp Med. 1997 Mar 17;185(6):1065-75. doi: 10.1084/jem.185.6.1065.
4
In vivo responses of mouse blood cells to platelet-activating factor (PAF): role of the mediators of anaphylaxis.小鼠血细胞对血小板活化因子（PAF）的体内反应：过敏反应介质的作用。
Agents Actions. 1993 Nov;40(3-4):150-6. doi: 10.1007/BF01984054.
5
Altered inflammatory responses in leukotriene-deficient mice.白三烯缺陷小鼠的炎症反应改变。
Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12852-6. doi: 10.1073/pnas.91.26.12852.
6
Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia.血小板活化因子在急性心肌缺血中加重缺血的作用
Basic Res Cardiol. 1985 Mar-Apr;80(2):135-41. doi: 10.1007/BF01910460.
7
Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration.花生四烯酸代谢抑制剂对血小板活化因子诱导的胃黏膜坏死和血液浓缩的影响。
Br J Pharmacol. 1986 Oct;89(2):415-22. doi: 10.1111/j.1476-5381.1986.tb10275.x.
8
Catecholamines released from the adrenal medulla exert a compensatory, protective effect at beta 2-adrenoceptors against Paf-induced death in mice.从肾上腺髓质释放的儿茶酚胺在β2 -肾上腺素能受体处对血小板活化因子诱导的小鼠死亡发挥代偿性保护作用。
Br J Pharmacol. 1988 Jan;93(1):132-8. doi: 10.1111/j.1476-5381.1988.tb11413.x.
9
Paf-acether-induced death in mice: involvement of arachidonate metabolites and beta-adrenoceptors.血小板活化因子诱导的小鼠死亡：花生四烯酸代谢产物和β-肾上腺素能受体的参与
Br J Pharmacol. 1987 Jan;90(1):203-9. doi: 10.1111/j.1476-5381.1987.tb16841.x.
10
Prevention of non-specific airway hyperreactivity after allergen challenge in guinea-pigs by the PAF receptor antagonist SDZ 64-412.血小板活化因子受体拮抗剂SDZ 64 - 412对豚鼠变应原激发后非特异性气道高反应性的预防作用
Br J Pharmacol. 1990 Feb;99(2):396-400. doi: 10.1111/j.1476-5381.1990.tb14715.x.
本文引用的文献
1
2
Platelet-activating factor acether (PAF-acether) involvement in acute inflammatory and pain processes.血小板活化因子乙醚（PAF-乙醚）参与急性炎症和疼痛过程。
Agents Actions. 1981 Dec;11(6-7):559-62. doi: 10.1007/BF01978740.
3
4
[Platelet aggregation and platelet activating factor (author's transl)].血小板聚集与血小板激活因子（作者译）
J Pharmacol. 1980 Oct-Dec;11(4):371-7.
5
Protective effects of the glucocorticoid, budesonide, on lung anaphylaxis in actively sensitized guinea-pigs: inhibition of IgE-but not of IgG-mediated anaphylaxis.糖皮质激素布地奈德对主动致敏豚鼠肺部过敏反应的保护作用：抑制IgE介导而非IgG介导的过敏反应。
Br J Pharmacol. 1982 May;76(1):139-47. doi: 10.1111/j.1476-5381.1982.tb09199.x.
6
Effect of platelet-activating factor (PAF) on human platelets.血小板活化因子（PAF）对人血小板的作用。
Blood. 1982 Mar;59(3):582-5.
7
Background and present status of research on platelet-activating factor (PAF-acether).血小板活化因子（PAF-乙酰醚）的研究背景与现状
Ann N Y Acad Sci. 1981;370:119-37. doi: 10.1111/j.1749-6632.1981.tb29727.x.
8
Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives.血小板活化因子可诱导一种与前列腺素衍生物形成无关的血小板依赖性支气管收缩。
Eur J Pharmacol. 1980 Jul 25;65(2-3):185-92. doi: 10.1016/0014-2999(80)90391-x.
9
Thromboxane agonism and antagonism in a mouse sudden death model.小鼠猝死模型中的血栓素激动与拮抗作用
J Pharmacol Exp Ther. 1983 Feb;224(2):369-72.
10
Inhibition by sulphinpyrazone of the platelet-dependent bronchoconstriction due to platelet-activating factor (PAF-acether) in the guinea pig.在豚鼠中，磺吡酮对血小板活化因子（PAF-乙酰醚）所致的血小板依赖性支气管收缩的抑制作用。
Eur J Pharmacol. 1982 Feb 19;78(1):71-9. doi: 10.1016/0014-2999(82)90373-9.
Zotero 插件