Kitzis M, Weiss A M, Michel F, Giuli R, Nussaume O, Monteau M, Dournovo P, Thibault P
Nouv Presse Med. 1981 Nov 14;10(41):3397-400.
The authors report on three cases of thymic seminoma treated between 1971 and 1981. These tumours, first described by Friedman in 1981. These tumours, first described by Friedman in 1951, belong to the group of extra-gonadal germinal tumours. They constitute about 2.5% of all thymic masses. The most probable pathogenic theory is abnormal migration of germinal cells from the vitelline sac to the embryonic thymus. Thymic seminomas are usually found in young men and are asymptomatic in 30% of the cases. Macroscopically, they present as solid tumours capable of invading the surrounding structures. Histologically, they resemble gonadal seminomas but are sometimes difficult to identify, which is unfortunate since treatment is dependent upon an accurate histological diagnosis. The authors suggest that the tumour should be biopsied under mediastinal fluoroscopy, so that an accurate histological diagnosis can be made. Treatment consists of surgical excision, which should be restricted and on no account should destroy important structures, completed by mediastinal radiotherapy. The mean survival time is 6.3 years; the 5-year survival rate is 75%.
作者报告了1971年至1981年间治疗的3例胸腺精原细胞瘤。这些肿瘤最早由弗里德曼于1951年描述，属于性腺外生殖细胞瘤组。它们约占所有胸腺肿物的2.5%。最可能的致病理论是生殖细胞从卵黄囊异常迁移至胚胎胸腺。胸腺精原细胞瘤通常见于年轻男性，30%的病例无症状。大体上，它们表现为能够侵犯周围结构的实体瘤。组织学上，它们类似于性腺精原细胞瘤，但有时难以识别，这很不幸，因为治疗取决于准确的组织学诊断。作者建议应在纵隔荧光镜检查下对肿瘤进行活检，以便做出准确的组织学诊断。治疗包括手术切除，手术应有所限制，绝不应破坏重要结构，术后辅以纵隔放疗。平均生存时间为6.3年；5年生存率为75%。
