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鼻咽癌与组织相容性抗原

Nasopharyngeal carcinoma and histocompatibility antigens.

作者信息

Simons M J, Chan S H, Wee G B, Shanmugaratnam K, Goh E H, Ho J H, Chau J C, Darmalingam S, Prasad U, Betuel H, Day N E, de-The G

出版信息

IARC Sci Publ (1971). 1978(20):271-82.

PMID:730194
Abstract

New data are presented concerning the relationship between NPC and HLA antigens among Chinese. When attention is confined to newly diagnosed cases, it can be shown that, apart from the increased risk associated with the joint occurrence of A2 and B-Sin 2, there is also an increased risk associated with BW17 and a decrease in risk associated with A11. Among long-term survivors, however, BW17 is appreciably decreased, whereas A2 in the absence of B-Sin 2 or BW17 is increased. Among Malays, a non-Chinese group, there is an excess among NPC patients of a locus A blank, a blank which is probably associated with the AW19 complex.

摘要

本文给出了有关中国人鼻咽癌(NPC)与人类白细胞抗原(HLA)抗原之间关系的新数据。若仅关注新诊断病例,可发现,除了与A2和B-Sin 2共同出现相关的风险增加外,与BW17相关的风险也增加,而与A11相关的风险降低。然而,在长期存活者中,BW17明显减少,而在不存在B-Sin 2或BW17时A2增加。在非华裔人群马来人中,NPC患者中存在A位点空白过多的情况,该空白可能与AW19复合体相关。

相似文献

1
Nasopharyngeal carcinoma and histocompatibility antigens.鼻咽癌与组织相容性抗原
IARC Sci Publ (1971). 1978(20):271-82.
2
Immunogenetic aspects of nasopharyngeal carcinoma (NPC) III. HL-a type as a genetic marker of NPC predisposition to test the hypothesis that Epstein-Barr virus is an etiological factor in NPC.鼻咽癌(NPC)的免疫遗传学研究 Ⅲ. 作为鼻咽癌易感性遗传标志物的HL-a型,以检验爱泼斯坦-巴尔病毒是鼻咽癌病因学因素这一假说。
IARC Sci Publ (1971). 1975(11 Pt 2):249-58.
3
Immunogenetics of nasopharyngeal carcinoma--position in 1980.
Ann Acad Med Singap. 1980 Jul;9(3):296-9.
4
[Correlation between nasopharyngeal carcinoma (NPC) and HLA in Hunan Province].
Zhonghua Zhong Liu Za Zhi. 1986 May;8(3):170-2.
5
Immunogenetic aspects of nasopharyngeal carcinoma. V. Confirmation of a Chinese-related HLA profile (A2, Singapore 2) associated with an increased risk in Chinese for nasopharyngeal carcinoma.
Natl Cancer Inst Monogr. 1977 Dec;47:147-51.
6
Histocompatibility leukocyte antigen patterns and nasopharyngeal carcinoma.组织相容性白细胞抗原模式与鼻咽癌
Natl Cancer Inst Monogr. 1977 Dec;47:143-6.
7
[Correlation between nasopharyngeal carcinoma and HLA in Sichuan].[四川地区鼻咽癌与人类白细胞抗原的相关性]
Zhonghua Zhong Liu Za Zhi. 1988 Jul;10(4):263-6.
8
Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region.
Nature. 1990 Aug 2;346(6283):470-1. doi: 10.1038/346470a0.
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HLA associations with nasopharyngeal carcinoma in Southern Chinese: a meta-analysis.
Clin Otolaryngol Allied Sci. 2002 Feb;27(1):61-7. doi: 10.1046/j.0307-7772.2001.00529.x.
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General immunological status of nasopharyngeal carcinoma patients in Singapore.新加坡鼻咽癌患者的一般免疫状态。
IARC Sci Publ (1971). 1978(20):495-501.

引用本文的文献

1
HLA-A*02-B*46 haplotype: an adverse prognostic factor in Han patients with nasopharyngeal carcinoma.HLA-A*02-B*46单倍型:汉族鼻咽癌患者的不良预后因素
J Huazhong Univ Sci Technolog Med Sci. 2016 Oct;36(5):700-704. doi: 10.1007/s11596-016-1647-y. Epub 2016 Oct 18.
2
Nasopharyngeal carcinoma as a paradigm of cancer genetics.鼻咽癌作为癌症遗传学的一个范例。
Chin J Cancer. 2011 Feb;30(2):79-84. doi: 10.5732/cjc.010.10609.