Yonas H, Wolfson S K, Dujovny M, Boehnke M, Cook E
Stroke. 1981 Sep-Oct;12(5):567-72. doi: 10.1161/01.str.12.5.567.
A highly reliable model for the study of focal cerebral ischemia has been developed using a retro-orbital approach to occlude the lateral lenticulostriate arteries of the baboon. An infarction of the caudate, putamen and the anterior limb of the internal capsule has consistently been produced. Reliability has been attained because the anatomical variations of the lenticulostriate arteries of each animal can be fully appraised, permitting selective vessel occlusion. A well-defined clinical and radiographic lesion has also resulted from this procedure which was clinically well tolerated by all animals. Selective lenticulostriate occlusion provides a new approach to the study of focal cerebral ischemia in the sub-human primate, and serves for the evaluation of proposed therapies for treatment of focal cerebral ischemia.
通过眶后入路闭塞狒狒的外侧豆纹动脉，已开发出一种用于研究局灶性脑缺血的高度可靠模型。尾状核、壳核和内囊前肢一直会出现梗死。该模型具有可靠性，因为可以全面评估每只动物豆纹动脉的解剖变异情况，从而实现选择性血管闭塞。此操作还产生了明确的临床和影像学病变，所有动物在临床上对该操作耐受性良好。选择性豆纹动脉闭塞为研究非人灵长类动物的局灶性脑缺血提供了一种新方法，可用于评估针对局灶性脑缺血的拟议治疗方法。
