霍乱弧菌在幼鼠上消化道中的存活与繁殖
Survival and multiplication of Vibrio cholerae in the upper bowel of infant mice.
作者信息
Baselski V S, Medina R A, Parker C D
出版信息
Infect Immun. 1978 Nov;22(2):435-40. doi: 10.1128/iai.22.2.435-440.1978.
Abstract
The survival and multiplication of Vibrio cholerae strains of varying virulence in the upper bowel of orally challenged infant mice early in infection has been examined. Analysis of changes in the apparent specific activity (counts per minute per colony-forming unit) of the cell population after 4 h compared with the inoculum indicated that strain CA401 established a viable, multiplying cell population, whereas strains VB12 (a rough variant) and 569B were subject to host bactericidal and bacteriolytic mechanisms. An analysis of parameters which may affect the specific activity is included. We have defined the infective potential of the strains in terms of the changes in specific activity. The relative infective potentials are CA401 greater than 569B greater than VB12.
摘要
研究了不同毒力的霍乱弧菌菌株在感染早期经口感染的幼鼠上消化道中的存活和增殖情况。与接种物相比，分析感染4小时后细胞群体表观比活性（每分钟每菌落形成单位的计数）的变化表明，CA401菌株建立了一个存活且增殖的细胞群体，而VB12菌株（一种粗糙变体）和569B菌株则受到宿主的杀菌和溶菌机制作用。文中还包括了对可能影响比活性的参数的分析。我们根据比活性的变化定义了菌株的感染潜力。相对感染潜力为CA401大于569B大于VB12。
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