C3H/HeJ和C3H/HeN小鼠及其腹腔巨噬细胞对鹦鹉热衣原体原体毒性的反应。
Response of C3H/HeJ and C3H/HeN mice and their peritoneal macrophages to the toxicity of Chlamydia psittaci elementary bodies.
作者信息
Ivins B E, Wyrick P B
出版信息
Infect Immun. 1978 Nov;22(2):620-2. doi: 10.1128/iai.22.2.620-622.1978.
Abstract
Intravenous injection of toxic doses of Chlamydia psittaci elementary bodies into endotoxin-responsive C3H/HeN mice or endotoxin-nonresponsive C3H/HeJ mice resulted in essentially identical time intervals to death. Inoculation of monolayer cultures of thioglycolate-stimulated peritoneal macrophages from the two strains of mice with 250 elementary bodies per macrophage resulted in immediate host cell toxicity, although the C3H/HeJ macrophages were somewhat less sensitive to elementary body toxicity than were the C3H/HeN macrophages.
摘要
向内毒素反应性C3H/HeN小鼠或内毒素无反应性C3H/HeJ小鼠静脉注射有毒剂量的鹦鹉热衣原体原体，导致至死亡的时间间隔基本相同。用每巨噬细胞250个原体接种来自这两种小鼠品系的经巯基乙酸盐刺激的腹膜巨噬细胞单层培养物，会立即产生宿主细胞毒性，尽管C3H/HeJ巨噬细胞对原体毒性的敏感性略低于C3H/HeN巨噬细胞。
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