Hawkes R A, Boughton C R, Ferguson V
Am J Epidemiol. 1981 Oct;114(4):554-62. doi: 10.1093/oxfordjournals.aje.a113221.
Sera from 988 subjects in four ecologic zones of the Sepik district and 219 subjects from four widely spaced altitudes of the bismarck range in Papua New Guinea were tested for antibody to the hepatitis A virus (anti-HAV) by radioimmunoassay. The Sepik district subjects, mostly children between three months and six years of age when first sampled in 1963, were re-bled on four occasions over the ensuing nine years. The Bismarck range population was sampled only in 1964. In the Sepik district, anti-HAV was detected infrequently before the age of three years and showed maximum increase in prevalence rates between 7-10 years, with little increase thereafter. Antibody acquisition rates also indicated peak transmission in this age group, with fewer conversions between three months and six years of age and in adulthood. There was a consistent, though unexplained tendency for HAV infections to occur more frequently in proximity to the Sepik river than in areas farther away, and in the lower altitudes of the Bismarck range. As determined by serial samples, anti-HAV detected in 1963-1964 was still present in 1972 in 118 out of 119 subjects.
采用放射免疫分析法，对来自巴布亚新几内亚塞皮克地区四个生态区的988名受试者以及来自俾斯麦山脉四个间隔较远海拔高度的219名受试者的血清进行了甲型肝炎病毒抗体（抗-HAV）检测。塞皮克地区的受试者大多是1963年首次采样时年龄在3个月至6岁之间的儿童，在随后的9年里又进行了4次采血。俾斯麦山脉的人群仅在1964年进行了采样。在塞皮克地区，3岁前很少检测到抗-HAV，患病率在7至10岁之间增幅最大，此后增幅很小。抗体获得率也表明该年龄组传播高峰，3个月至6岁以及成年期的血清转化较少。在塞皮克河附近比在更远地区以及俾斯麦山脉较低海拔地区，甲型肝炎病毒感染出现得更频繁，这一趋势始终存在，尽管原因不明。通过系列样本测定，1963 - 1964年检测到的抗-HAV在1972年时，119名受试者中有118名仍存在。
