脆弱拟杆菌群对四环素、红霉素和克林霉素的耐药性：诱导性与组成性四环素耐药性
Resistance to tetracycline, erythromycin, and clindamycin in the Bacteroides fragilis group: inducible versus constitutive tetracycline resistance.
作者信息
Privitera G, Fayolle F, Sebald M
出版信息
Antimicrob Agents Chemother. 1981 Sep;20(3):314-20. doi: 10.1128/AAC.20.3.314.
Abstract
The transferability of plasmid-mediated tetracycline, erythromycin, and clindamycin resistance was studied in 63 clinical isolates of the Bacteroides fragilis group. Of 48 strains which were tetracycline resistant (Tcr), the regulation of both the expression of Tcr and its transferability was shown to be under inducible control by tetracycline. In 29 of the strains, Tcr was transferable; in the majority of these (26 strains), transferability was inducible (Trai) and it was constitutive (Trac) in only 3 strains. All four possible phenotypes were found (Tci Trai, Tci Trac, Tcc Trai, and Tcc Trac), which indicates independent control of both Tcr expression and its transferability. Resistance to erythromycin and clindamycin was cotransferred with Tcr in 14 of the 48 Tcr strains and transferred independently of Tcr in only 1 strain.
摘要
在63株脆弱拟杆菌属临床分离株中研究了质粒介导的四环素、红霉素和克林霉素耐药性的可转移性。在48株四环素耐药（Tcr）菌株中，Tcr表达及其可转移性的调控均显示受四环素的诱导控制。在29株菌株中，Tcr是可转移的；在其中大多数（26株）中，可转移性是诱导性的（Trai），只有3株是组成型的（Trac）。发现了所有四种可能的表型（Tci Trai、Tci Trac、Tcc Trai和Tcc Trac），这表明Tcr表达及其可转移性是独立控制的。在48株Tcr菌株中的14株中，对红霉素和克林霉素的耐药性与Tcr共转移，仅在1株中与Tcr独立转移。
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Resistance to tetracycline, erythromycin, and clindamycin in the Bacteroides fragilis group: inducible versus constitutive tetracycline resistance.脆弱拟杆菌群对四环素、红霉素和克林霉素的耐药性：诱导性与组成性四环素耐药性
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