Privitera G, Dublanchet A, Sebald M
J Infect Dis. 1979 Jan;139(1):97-101. doi: 10.1093/infdis/139.1.97.
Resistance to clindamycin, erythromycin, streptogramins, and tetracycline was shown to be transferable from a clinical isolate of Bacteroides fragilis subspecies distasonis to a sensitive strain of B. fragilis subspecies fragilis. Resistance to clindamycin, erythromycin, and streptogramins was transferable from a clinical isolate of B. fragilis subspecies fragilis to the sensitive strain of B. fragilis subspecies fragilis. Except for tetracycline, resistance to all of these antibiotics was spontaneously curable en bloc at a frequency of approximately 10(-2). These results suggest that resistance to these antibiotics is determined by a plasmid.
研究表明，对克林霉素、红霉素、链阳菌素和四环素的耐药性可从脆弱拟杆菌迟缓亚种的临床分离株转移至脆弱拟杆菌脆弱亚种的敏感菌株。对克林霉素、红霉素和链阳菌素的耐药性可从脆弱拟杆菌脆弱亚种的临床分离株转移至脆弱拟杆菌脆弱亚种的敏感菌株。除四环素外，对所有这些抗生素的耐药性可约以10^(-2)的频率整体自发消除。这些结果表明，对这些抗生素的耐药性是由质粒决定的。
