底特律地区四家医院中脆弱拟杆菌药敏模式的变异性。
Variability in the susceptibility pattern of Bacteroides fragilis in four Detroit area hospitals.
作者信息
Bawdon R E, Rozmiej E, Palchaudhuri S, Krakowiak J
出版信息
Antimicrob Agents Chemother. 1979 Nov;16(5):664-6. doi: 10.1128/AAC.16.5.664.
Abstract
Recent clinical isolates of Bacteroides fragilis selected at random from four Detroit area hospitals were collected over a 3-month period, and the minimum inhibitory concentrations were determined within several days. The levels of antimicrobial agents used in this survey breached the concentration attainable in the patient's serum. The antimicrobial susceptibility patterns of these isolates to five antimicrobial agents suggest that there is a 20% variation in the resistance to clindamycin and also up to 20% variation among the other four antibiotics in the four area hospitals. The changing susceptibility pattern of B. fragilis to antibiotic resistance suggests that minimum inhibitory concentrations should be determined for all isolates from serious clinical infections.
摘要
在三个月的时间里，从底特律地区四家医院随机选取了近期分离出的脆弱拟杆菌临床菌株，并在数天内测定了其最低抑菌浓度。本次调查中使用的抗菌剂水平超过了患者血清中可达到的浓度。这些菌株对五种抗菌剂的药敏模式表明，四家医院的菌株对克林霉素的耐药性存在20%的差异，对其他四种抗生素的耐药性差异也高达20%。脆弱拟杆菌对抗生素耐药性的药敏模式变化表明，对于所有严重临床感染分离株都应测定最低抑菌浓度。
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