Sano Y, Nishimukai H, Kitamura H, Nagaki K, Inai S, Hamasaki Y, Maruyama I, Igata A
Arthritis Rheum. 1981 Oct;24(10):1255-60. doi: 10.1002/art.1780241005.
We observed two sisters with lupus-like syndrome with homozygous C3 deficiencies. A 19-year-old woman and her 15-year-old sister developed malar rash, arthralgia, and photosensitivity, but antinuclear antibodies and LE cell preparations were negative. The older sister experienced recurrent bronchitis in her childhood, but the younger sister had no recurrent infections. Serum C3 was not detected immunochemically in either sister, and total complement activity and C3 hemolytic activity were extremely low.
我们观察了两名患有纯合子C3缺乏症的狼疮样综合征姐妹。一名19岁女性及其15岁妹妹出现了颧部皮疹、关节痛和光过敏，但抗核抗体和LE细胞检查均为阴性。姐姐童年时有反复支气管炎发作，但妹妹没有反复感染史。两名姐妹的血清C3均未通过免疫化学方法检测到，总补体活性和C3溶血活性极低。
