小鼠和大鼠皮肤中DNA与苯并[a]芘4,5-环氧化物共价加合物的形成。
Formation of covalent deoxyribonucleic acid benzo[a]pyrene 4,5-epoxide adduct in mouse and rat skin.
作者信息
Baer-Dubowska W, Frayssinet C, Alexandrov K
出版信息
Cancer Lett. 1981 Nov;14(2):125-9. doi: 10.1016/0304-3835(81)90121-x.
PMID:7317876
Abstract
The covalently bound products of [3H]benzo[a]pyrene (BP) were determined in the DNA from the skin of mice and rats. The quality and the distribution of bound products was similar. The formation of products corresponding to 4,5-dihydro-4,5-epoxy benzo[a]pyrene (BPE) and to a further metabolite of 9-hydroxybenzo[a]pyrene bound to DNA were found in the 2 species at the 24 h end point.
摘要
测定了[3H]苯并[a]芘（BP）与小鼠和大鼠皮肤DNA的共价结合产物。结合产物的性质和分布相似。在24小时的时间点，在这两个物种中均发现了与4,5-二氢-4,5-环氧苯并[a]芘（BPE）以及9-羟基苯并[a]芘的另一种代谢产物相对应的结合到DNA上的产物。
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