Croft W A, Lower G M
Cancer Lett. 1981 Jul;13(2):175-9. doi: 10.1016/0304-3835(81)90146-4.
Guinea pigs were observed to be refractory to carcinogenesis by 3 different carcinogenic 5-nitrofurans administered at 0.1% of the diet for 50 weeks followed by 74 weeks of control diet. In view of the evidenced involvement of nitroreduction in the metabolic activation of 5-nitrofurans, it is of interest that guinea pig refractoriness is not due to a quantitative nitroreductase deficiency in guinea pig liver.
将豚鼠的饮食中添加0.1%的3种不同致癌性5-硝基呋喃，持续50周，随后给予74周的对照饮食，结果发现豚鼠对致癌作用具有抗性。鉴于有证据表明硝基还原参与5-硝基呋喃的代谢活化，豚鼠的抗性并非由于其肝脏中硝基还原酶的定量缺乏，这一点很有意思。
