Uslenghi E, Donegani E, Forni B, Baroni F, Zardini P
G Ital Cardiol. 1981;11(7):973-8.
12 patients suffering from chronic coronary insufficiency with signs of ischemia in the ECG, were treated orally with 200 mg of acebutolol t.i.d. for a period of 3 weeks. The following parameters were examined at the beginning of the therapy as well as at the end of every week: number of stenocardiac attacks, characteristics of pain, nitroglycerin consumption, B.P., H.R., respiratory rate, ECG, maximal exercise test, PEP, LVET, PEP/LVET at rest and immediately after effort. The treatment with acebutolol was effective inducing an improvement of subjective symptoms (reduction of stenocardiac crises, intensity and duration of angor, trinitrin pearls consumption) and an increase of effort tolerance. The utility of the therapy was also proved by the reduction of the systolic pressure and by the following decrease of hemodynamic overload and, therefore, of the heart muscle's work. This positive effect is due to the reduction of the myocardial oxygen consumption, modulated among others by the bradycardiac action of the drug. The cardioselectivity of acebutolol avoided to cause peripherical disorders usually observed with other non selective beta blocking drugs.
12名患有慢性冠状动脉供血不足且心电图有缺血迹象的患者，口服醋丁洛尔，每次200毫克，每日三次，持续3周。在治疗开始时以及每周结束时检查以下参数：心绞痛发作次数、疼痛特征、硝酸甘油消耗量、血压、心率、呼吸频率、心电图、最大运动试验、射血前期（PEP）、左室射血时间（LVET）、静息时和运动后即刻的PEP/LVET。醋丁洛尔治疗有效，可改善主观症状（减少心绞痛发作、减轻心绞痛的强度和持续时间、减少硝酸甘油含片消耗量）并提高运动耐量。收缩压降低以及随后血流动力学负荷的减轻，进而心肌工作负担的减轻，也证明了该疗法的有效性。这种积极作用归因于心肌耗氧量的减少，药物的减慢心率作用等对其有调节作用。醋丁洛尔的心脏选择性避免了通常在其他非选择性β受体阻滞剂中观察到的外周紊乱。
