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1
Release of vasoactive intestinal polypeptide from the cat small intestine exposed to cholera toxin.暴露于霍乱毒素的猫小肠中血管活性肠肽的释放。
Gut. 1981 Nov;22(11):958-63. doi: 10.1136/gut.22.11.958.
2
Somatostatin and methionine-enkephalin inhibit cholera toxin-induced jejunal net fluid secretion and release of vasoactive intestinal polypeptide in the cat in vivo.生长抑素和甲硫氨酸脑啡肽在体内可抑制猫霍乱毒素诱导的空肠净液体分泌及血管活性肠肽的释放。
Acta Physiol Scand. 1988 Aug;133(4):551-7. doi: 10.1111/j.1748-1716.1988.tb08440.x.
3
The involvement of intramural nerves in cholera toxin induced intestinal secretion.壁内神经在霍乱毒素诱导的肠道分泌中的作用。
Acta Physiol Scand. 1983 Feb;117(2):195-202. doi: 10.1111/j.1748-1716.1983.tb07197.x.
4
Intestinal secretion induced by vasoactive intestinal polypeptide. A comparison with cholera toxin in the canine jejunum in vivo.血管活性肠肽诱导的肠分泌。与霍乱毒素在犬空肠体内的比较。
J Clin Invest. 1978 May;61(5):1337-45. doi: 10.1172/JCI109051.
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Changes in cyclic 3'5'-adenosine monophosphate tissue concentration and net fluid transport in the cat's small intestine elicited by cholera toxin, arachidonic acid, vasoactive intestinal polypeptide and 5-hydroxytryptamine.霍乱毒素、花生四烯酸、血管活性肠肽和5-羟色胺引起的猫小肠中3',5'-环磷酸腺苷组织浓度和净液体转运的变化。
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7
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Cholera toxin-induced small intestinal secretion has a secretory effect on the colon of the rat.霍乱毒素诱导的小肠分泌对大鼠结肠有分泌作用。
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The enteric nervous system and neurogastroenterology.肠神经系统与神经胃肠病学。
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Enteroendocrine and neuronal mechanisms in pathophysiology of acute infectious diarrhea.肠内分泌和神经元机制在急性感染性腹泻的病理生理学中的作用。
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本文引用的文献

1
On the role of intramural nerves in the pathogenesis of cholera toxin-induced intestinal secretion.关于壁内神经在霍乱毒素诱导的肠道分泌发病机制中的作用
Scand J Gastroenterol. 1981 Apr;16(3):377-84. doi: 10.3109/00365528109181984.
2
Effect of vagotomy and glucose administration on gastric acid secretion in the Atlantic cod, Gadus morhua.迷走神经切断术和葡萄糖给药对大西洋鳕鱼（Gadus morhua）胃酸分泌的影响。
Acta Physiol Scand. 1980 May;109(1):37-44. doi: 10.1111/j.1748-1716.1980.tb06561.x.
3
Relationship between local changes in cortical blood flow and extracellular K+ during spreading depression.扩散性抑制期间皮质血流局部变化与细胞外钾离子之间的关系。
Acta Physiol Scand. 1980 May;109(1):1-6. doi: 10.1111/j.1748-1716.1980.tb06557.x.
4
Peptide-containing neurones connect the two ganglionated plexuses of the enteric nervous system.含肽神经元连接肠神经系统的两个神经节丛。
Nature. 1980 Jan 24;283(5745):391-3. doi: 10.1038/283391a0.
5
Characterization of specific binding sites for vasoactive intestinal peptide in rat intestinal epithelial cell membranes.大鼠肠上皮细胞膜中血管活性肠肽特异性结合位点的特性分析。
Biochim Biophys Acta. 1980 Jan 17;627(2):215-24. doi: 10.1016/0304-4165(80)90323-2.
6
Distribution of enteric nerve cell bodies and axons showing immunoreactivity for vasoactive intestinal polypeptide in the guinea-pig intestine.豚鼠肠道中显示血管活性肠肽免疫反应性的肠神经细胞体和轴突的分布。
Neuroscience. 1980;5(3):587-96. doi: 10.1016/0306-4522(80)90056-1.
7
Distribution of peptide- and catecholamine-containing neurons in the gastro-intestinal tract of rat and guinea-pig: immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine beta-hydroxylase.大鼠和豚鼠胃肠道中含肽和儿茶酚胺神经元的分布：用P物质、血管活性肠肽、脑啡肽、生长抑素、胃泌素/胆囊收缩素、神经降压素和多巴胺β-羟化酶抗血清进行的免疫组织化学研究
Neuroscience. 1980;5(4):689-744. doi: 10.1016/0306-4522(80)90166-9.
8
Mesenteric vasomotor effects of vasoactive intestinal polypeptide. Study on perfused isolated canine jejunal loops.血管活性肠肽对肠系膜的血管舒缩作用。对灌注的离体犬空肠袢的研究。
Pflugers Arch. 1974;352(1):37-46. doi: 10.1007/BF01061948.
9
Localization of vasoactive intestinal polypeptide (VIP) to central and peripheral neurons.血管活性肠肽（VIP）在中枢和外周神经元中的定位。
Proc Natl Acad Sci U S A. 1976 Sep;73(9):3197-200. doi: 10.1073/pnas.73.9.3197.
10
Influence of the autonomic nervous system on the release of vasoactive intestinal polypeptide from the porcine gastrointestinal tract.自主神经系统对猪胃肠道血管活性肠肽释放的影响。
J Physiol. 1978 Jul;280:405-22. doi: 10.1113/jphysiol.1978.sp012391.

暴露于霍乱毒素的猫小肠中血管活性肠肽的释放。

Release of vasoactive intestinal polypeptide from the cat small intestine exposed to cholera toxin.

作者信息

Cassuto J, Fahrenkrug J, Jodal M, Tuttle R, Lundgren O

出版信息

Gut. 1981 Nov;22(11):958-63. doi: 10.1136/gut.22.11.958.

DOI:10.1136/gut.22.11.958
PMID:7308850
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1419474/
Abstract

During a four hour observation period vasoactive intestinal polypeptide (VIP) is released in increasing amounts from the feline small intestine exposed to cholera toxin. As VIP is known to be located almost exclusively in the intestinal nerves, the present findings strongly suggest that cholera toxin activates the enteric nervous system. The findings of this and other studies performed in this laboratory lead to the proposal that the choleraic secretion is, at least in part, secondary to the activation of intramural nervous reflexes in the gut.

摘要

在四小时的观察期内，血管活性肠肽（VIP）从暴露于霍乱毒素的猫小肠中释放量不断增加。由于已知VIP几乎仅存在于肠神经中，目前的研究结果强烈表明霍乱毒素激活了肠神经系统。本实验室进行的这项研究及其他研究结果提示，霍乱性分泌至少部分是肠道壁内神经反射激活的继发结果。