Westley J W, Evans R H, Sello L H, Troupe N, Liu C, Miller P A
J Antibiot (Tokyo). 1981 Oct;34(10):1248-52. doi: 10.7164/antibiotics.34.1248.
Antibiotics X-14667A (1) and X-14667B (2) are novel monovalent polyether antibiotics of the spiroketal type isolated from fermented cultures of Streptomyces cinnamonensis subsp. urethanofaciens together with monensin (3), its lower homolog, factor B (4) and 1,3-diphenethylurea (6). By a combination of microanalysis, mass spectrometry and 13C nmr, antibiotics X-14667A and B have been shown to be natural 2-phenethylurethanes of monensin B and A respectively. Both structures have been confirmed by reacting the appropriate monensin with 2-phenethylisocyanate to yield semi-synthetic compounds that are identical to the natural products.
抗生素X-14667A（1）和X-14667B（2）是新型的单链螺旋缩酮类聚醚抗生素，从肉桂链霉菌亚种尿烷产生菌的发酵培养物中分离得到，同时还有莫能菌素（3）、其低级同系物B因子（4）和1,3 - 二苯乙基脲（6）。通过微量分析、质谱分析和13C核磁共振的综合方法，已表明抗生素X-14667A和B分别是莫能菌素B和A的天然2 - 苯乙基氨基甲酸酯。通过使适当的莫能菌素与2 - 苯乙基异氰酸酯反应生成与天然产物相同的半合成化合物，已证实了这两种结构。
