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1
Production of 26-deoxymonensins A and B by Streptomyces cinnamonensis in the presence of Metyrapone.肉桂链霉菌在美替拉酮存在下产生26-脱氧莫能菌素A和B 。
Appl Environ Microbiol. 1994 May;60(5):1561-4. doi: 10.1128/aem.60.5.1561-1564.1994.
2
Selection of a specifically blocked mutant of Streptomyces cinnamonensis: isolation and synthesis of 26-deoxymonensin A.肉桂链霉菌特定阻断突变体的筛选：26-脱氧莫能菌素A的分离与合成
J Antibiot (Tokyo). 1989 Jul;42(7):1088-99. doi: 10.7164/antibiotics.42.1088.
3
[Induction of antibiotic production in inactive cultures of actinomycetes. Monensin production by a mutant strain 2608 EB-1].
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4
2-Demethylmonensins A and B. Novel minor congeners of monensins from Streptomyces cinnamonensis.2-去甲基莫能菌素A和B。来自肉桂链霉菌的莫能菌素新的次要同源物。
J Antibiot (Tokyo). 1996 Sep;49(9):935-7. doi: 10.7164/antibiotics.49.935.
5
3-O-demethylmonensins A and B produced by Streptomyces cinnamonensis.肉桂链霉菌产生的3-O-去甲基莫能菌素A和B。
J Antibiot (Tokyo). 1987 Apr;40(4):555-7. doi: 10.7164/antibiotics.40.555.
6
Isolation of novel antibiotics X-14667A and X-14667B from Streptomyces cinnamonensis subsp. urethanofaciens and their characterization as 2-phenethylurethanes of monensins B and A.从肉桂链霉菌尿烷生成亚种中分离新型抗生素X-14667A和X-14667B及其作为莫能菌素B和A的2-苯乙基尿烷的表征
J Antibiot (Tokyo). 1981 Oct;34(10):1248-52. doi: 10.7164/antibiotics.34.1248.
7
MeaA, a putative coenzyme B12-dependent mutase, provides methylmalonyl coenzyme A for monensin biosynthesis in Streptomyces cinnamonensis.MeaA是一种假定的依赖辅酶B12的变位酶，为肉桂链霉菌中莫能菌素的生物合成提供甲基丙二酰辅酶A。
J Bacteriol. 2001 Mar;183(6):2071-80. doi: 10.1128/JB.183.6.2071-2080.2001.
8
The biosynthesis of monensin-A: thymine, beta-aminoisobutyrate and methacrylate metabolism in Streptomyces cinnamonensis.莫能菌素-A的生物合成：肉桂链霉菌中的胸腺嘧啶、β-氨基异丁酸和甲基丙烯酸代谢
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Vitamins as effectors of monensin production by Streptomyces cinnamonensis.维生素作为肉桂链霉菌产生莫能菌素的效应物。
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10
Role of crotonyl coenzyme A reductase in determining the ratio of polyketides monensin A and monensin B produced by Streptomyces cinnamonensis.巴豆酰辅酶A还原酶在确定肉桂链霉菌产生的聚酮化合物莫能菌素A和莫能菌素B比例中的作用。
J Bacteriol. 1999 Nov;181(21):6806-13. doi: 10.1128/JB.181.21.6806-6813.1999.

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Front Microbiol. 2018 Aug 7;9:1840. doi: 10.3389/fmicb.2018.01840. eCollection 2018.
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Are There Any Other Compounds Isolated From Dermacoccus spp at All?是否从皮球菌属中分离出了其他任何化合物？
Curr Microbiol. 2017 Jan;74(1):132-144. doi: 10.1007/s00284-016-1152-3. Epub 2016 Oct 26.
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Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding.莫能菌素生物合成中的中间体：多醚离子载体莫能菌素生物合成的最后一步对于阳离子结合的完整性至关重要。
Beilstein J Org Chem. 2014 Feb 10;10:361-8. doi: 10.3762/bjoc.10.34. eCollection 2014.
4
Compounds isolated at the Institute of Microbiology in 1989-2001 and future trends.1989年至2001年在微生物研究所分离出的化合物及未来趋势。
Folia Microbiol (Praha). 2002;47(6):587-639. doi: 10.1007/BF02818663.

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Metabolism of metyrapone. III. Formation of an alpha-pyridone metabolite by rat hepatic soluble enzymes.
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Biosynthesis of monensin.莫能菌素的生物合成
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J Antibiot (Tokyo). 1987 Apr;40(4):555-7. doi: 10.7164/antibiotics.40.555.
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Purification and reconstitution of the electron transport components for 6-deoxyerythronolide B hydroxylase, a cytochrome P-450 enzyme of macrolide antibiotic (erythromycin) biosynthesis.6-脱氧红霉内酯B羟化酶电子传递组分的纯化与重组，6-脱氧红霉内酯B羟化酶是一种参与大环内酯类抗生素（红霉素）生物合成的细胞色素P-450酶。
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Selection of a specifically blocked mutant of Streptomyces cinnamonensis: isolation and synthesis of 26-deoxymonensin A.肉桂链霉菌特定阻断突变体的筛选：26-脱氧莫能菌素A的分离与合成
J Antibiot (Tokyo). 1989 Jul;42(7):1088-99. doi: 10.7164/antibiotics.42.1088.
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Molecular genetics of polyketides and its comparison to fatty acid biosynthesis.聚酮化合物的分子遗传学及其与脂肪酸生物合成的比较。
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An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea.
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Occurrence and biological function of cytochrome P450 monooxygenases in the actinomycetes.细胞色素P450单加氧酶在放线菌中的存在及生物学功能
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肉桂链霉菌在美替拉酮存在下产生26-脱氧莫能菌素A和B 。

Production of 26-deoxymonensins A and B by Streptomyces cinnamonensis in the presence of Metyrapone.

作者信息

Pospísil S, Sedmera P, Havlícek V, Tax J

机构信息

Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague.

出版信息

Appl Environ Microbiol. 1994 May;60(5):1561-4. doi: 10.1128/aem.60.5.1561-1564.1994.

DOI:10.1128/aem.60.5.1561-1564.1994
PMID:8017935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC201517/
Abstract

Metyrapone, a potent cytochrome P-450 inhibitor, added at 9 mM to a submerged culture of Streptomyces cinnamonensis caused partial inhibition of total monensin biosynthesis and coproduction of new metabolites, 26-deoxymonensins A and B. The latter was isolated as its 25-O-methyl derivative. Metyrapone was simultaneously reduced to metyrapol. All of these compounds were identified by nuclear magnetic resonance spectroscopy and mass spectrometry.

摘要

甲吡酮是一种有效的细胞色素P-450抑制剂，在9 mM的浓度下添加到肉桂链霉菌的深层培养物中，会部分抑制莫能菌素的总生物合成，并共同产生新的代谢产物26-脱氧莫能菌素A和B。后者以其25-O-甲基衍生物的形式被分离出来。甲吡酮同时被还原为甲吡醇。所有这些化合物均通过核磁共振光谱和质谱鉴定。