Gaillard M C, Ouvre E, Liégeois A, Lewin D
J Gynecol Obstet Biol Reprod (Paris). 1978 Sep;7(6):1043-50.
We have been able to show that fetal cells are able to survive and multiply in the haematopoietic organs of the pregnant mouse. We have been able to label fetal cells with a chromosome marker (T6) which is clearly visible in the metaphase of mitosis. It is not only that there is a considerable concentration of fetal cells in the maternal spleen (3 to 6 per cent) but there are several factors that suggest that these fetal cells can multiply there. These are, the presence of mitoses, long survival, and a rise in numbers in the case of a new pregnancy. Thus pregnancy seems to bring about a physiological "microchimerism".
我们已经能够证明，胎儿细胞能够在怀孕小鼠的造血器官中存活并增殖。我们已经能够用一种染色体标记（T6）标记胎儿细胞，这种标记在有丝分裂中期清晰可见。不仅母体脾脏中有相当数量的胎儿细胞（3%至6%），而且有几个因素表明这些胎儿细胞能够在那里增殖。这些因素包括有丝分裂的存在、长期存活以及再次怀孕时数量的增加。因此，怀孕似乎会导致一种生理性的“微嵌合体”。
