Fischbein A, Thornton J, Blumberg W E, Bernstein J, Valciukas J A, Moses M, Davidow B, Kaul B, Sirota M, Selikoff I J
Am J Public Health. 1980 Jul;70(7):697-700. doi: 10.2105/ajph.70.7.697.
The results of a cross-sectional clinical field survey of 90 telephone cable splicers are presented. Despite the rare occurrence of clinically overt lead poisoning among cable splicers, the observed prevalence of symptoms was 29% for lead-associated central nervous system symptoms and 21% for gastrointestinal symptoms. These two groups of symptoms were directly related to zinc protoporphyrin (ZPP) levels but no relationship was found between them and blood lead concentrations. Only 5% of the workers had significantly elevated blood lead levels (greater than 40 microgram/100ml). Because of the intermittent lead exposure encountered in this trade, individuals were identified with "normal" blood lead levels associated with "elevated" zinc protoporphyrin concentrations, indicating the difference in biological significance between exposure-(blood lead) and biological-response tests (ZPP). Suggestion is made that both types of diagnostic tests be utilized in the medical surveillance of lead-exposured workers.
本文展示了对90名电话电缆熔接工进行横断面临床现场调查的结果。尽管电缆熔接工中临床明显铅中毒的情况罕见,但观察到铅相关中枢神经系统症状的患病率为29%,胃肠道症状的患病率为21%。这两组症状与锌原卟啉(ZPP)水平直接相关,但未发现它们与血铅浓度之间存在关联。只有5%的工人血铅水平显著升高(大于40微克/100毫升)。由于该行业存在间歇性铅暴露,发现血铅水平“正常”但锌原卟啉浓度“升高”的个体,这表明暴露(血铅)和生物反应测试(ZPP)在生物学意义上存在差异。建议在对铅暴露工人进行医学监测时同时使用这两种诊断测试。