Hansen N E, Karle H
Scand J Haematol. 1979 Feb;22(2):173-8. doi: 10.1111/j.1600-0609.1979.tb00418.x.
Plasma lysozyme levels were studied in 42 patients with Hodgkin's disease and were found significantly increased. Plasma lysozyme varied with the stage of the disease and with symptoms, but did not correlate with the histological subtype or with blood neutrophil and monocyte counts. Serial measurements in four patients on MOPP treatment showed a rapid decrease following treatment. The increased plasma lysozyme in Hodgkin's disease stems most likely from the macrophage system, either because the macrophages are hyperactive and/or because the malignant cell in Hodgkin's disease is of macrophage origin.
对42例霍奇金病患者的血浆溶菌酶水平进行了研究，发现其显著升高。血浆溶菌酶水平随疾病分期和症状而变化，但与组织学亚型以及血液中性粒细胞和单核细胞计数无关。对4例接受MOPP治疗的患者进行的连续测量显示，治疗后血浆溶菌酶水平迅速下降。霍奇金病患者血浆溶菌酶升高最可能源于巨噬细胞系统，这要么是因为巨噬细胞过度活跃，要么是因为霍奇金病中的恶性细胞起源于巨噬细胞。
