Ree H J, Crowley J P, Leone L A
Cancer. 1981 Apr 15;47(8):1988-93. doi: 10.1002/1097-0142(19810415)47:8<1988::aid-cncr2820470815>3.0.co;2-4.
The clinical presentation of 71 untreated patients with Hodgkin's disease was studied in relation to immunohistochemically demonstrable lysozyme in the lymph node biopsy material. Sixty-one patients (86%) showed a positive staining reaction of varying degree, while ten (14%) showed no demonstrable lysozyme. The clinical features of lysozyme-positive patients differed markedly from those of lysozyme-negative patients. Stain-positive patients were younger (29 vs. 46), were more often in clinical Stage I or II disease (69% vs. 10%, P less than 0.001), and less frequently had constitutional symptoms (34% vs. 70%, P less than 0.02). Moreover, within the stain-positive group, patients who had the most intense staining reaction (mottling pattern) also had the most favorable clinical and histopathologic features at the time of diagnosis. The observations suggest that in Hodgkin's disease the lysozyme secretory activity of macrophage-histiocytes may be an important element of host resistance to neoplasia and that a depression of this secretory activity corresponds with disseminated disease.
对71例未经治疗的霍奇金病患者的临床表现进行了研究，这些研究与淋巴结活检材料中免疫组化可显示的溶菌酶有关。61例患者（86%）呈现不同程度的阳性染色反应，而10例（14%）未显示出可检测到的溶菌酶。溶菌酶阳性患者的临床特征与溶菌酶阴性患者明显不同。染色阳性患者更年轻（29岁对46岁），更多处于临床I期或II期疾病（69%对10%，P小于0.001），且较少出现全身症状（34%对70%，P小于0.02）。此外，在染色阳性组中，染色反应最强（斑点状模式）的患者在诊断时也具有最有利的临床和组织病理学特征。这些观察结果表明，在霍奇金病中，巨噬细胞-组织细胞的溶菌酶分泌活性可能是宿主对肿瘤形成的抵抗的一个重要因素，并且这种分泌活性的降低与播散性疾病相关。
