Carlsson A
Scand J Work Environ Health. 1981 Mar;7(1):51-5. doi: 10.5271/sjweh.2566.
Male rats were exposed to about 45 ppm of radioactively labeled xylene in the inspired air for 1--8 h. The distribution and elimination of xylene and metabolites in different organs and tissues were studied. To get an idea of the ratio between unmetabolized and metabolized xylene in organs and tissues, a supplementary study was performed in which five male rats were exposed to about 250 ppm of radioactively labeled xylene. The concentration of xylene and metabolites in the subcutaneous fat, where the largest amounts were found, displayed a sharp rise during the first 4 h of exposure in comparison with the following 4 h. Both during exposure and the decay phase the concentration of xylene and its metabolites in the cerebrum, cerebellum and muscles paralleled the arterial blood concentration and amounted to about 40% of the arterial blood value for xylene. The coefficient between the concentration of unmetabolized xylene in subcutaneous fat and inspiratory air was calculated to be 525 after 8 h of exposure.
将雄性大鼠置于吸入空气中含有约45 ppm放射性标记二甲苯的环境中1至8小时。研究了二甲苯及其代谢产物在不同器官和组织中的分布与消除情况。为了解器官和组织中未代谢二甲苯与代谢二甲苯的比例，进行了一项补充研究，将五只雄性大鼠置于含有约250 ppm放射性标记二甲苯的环境中。皮下脂肪中二甲苯及其代谢产物的含量最高，与随后4小时相比，暴露的前4小时其浓度急剧上升。在暴露期间和衰变阶段，大脑、小脑和肌肉中二甲苯及其代谢产物的浓度与动脉血浓度平行，约为动脉血中二甲苯值的40%。暴露8小时后，皮下脂肪中未代谢二甲苯浓度与吸入空气中二甲苯浓度的系数计算为525。
