Sann L, Rigal D, David L, Frederich A, Lahet C
Acta Paediatr Scand. 1981 Jul;70(4):479-84. doi: 10.1111/j.1651-2227.1981.tb05726.x.
The plasma concentrations of 25-hydroxycholecalciferol (25-OH-CC), immunoreactive parathyroid hormone (iPTH) and calcitonin (iCT) were measured at the age of 30 and 66 days in thirteen preterm neonates (birthweight: 970 to 1300 g). At the age of 30 days when all infants were fed only with breast milk (BM) serum iCT and iPTH levels were normal. During the second month 7 infants were fed with BM only (control group) and 6 infants were supplemented with formula (supplemented group). At the age of 66 days, mean +/- S.D. serum iPTH concentration was higher in the supplemented group than in the control group: 169 +/- 79 vs. 60 +/- 33 microliterEq/ml (p less than 0.01). Serum iCT levels remained undetectable (less than 150 pg/ml) in both groups. Plasma 25-OH-CC concentrations were normal and similar in both groups. Serum iPTH concentrations were positively correlated with phosphorus intake and negatively correlated with calcium intake from BM only. The results suggest that secondary hyperparathyroidism can be detected in very low birthweight infants supplemented with a formula, probably because of a phosphorus load or decreased intestinal absorption of calcium.
对13名早产儿（出生体重：970至1300克）在30日龄和66日龄时测定了25-羟胆钙化醇（25-OH-CC）、免疫反应性甲状旁腺激素（iPTH）和降钙素（iCT）的血浆浓度。在30日龄时，所有婴儿仅母乳喂养，血清iCT和iPTH水平正常。在第二个月，7名婴儿仅母乳喂养（对照组），6名婴儿添加配方奶（添加组）。在66日龄时，添加组的平均±标准差血清iPTH浓度高于对照组：169±79对60±33微升Eq/ml（p<0.01）。两组血清iCT水平均未检测到（<150 pg/ml）。两组血浆25-OH-CC浓度正常且相似。血清iPTH浓度与磷摄入量呈正相关，与仅从母乳中摄入的钙呈负相关。结果表明，在添加配方奶的极低出生体重婴儿中可检测到继发性甲状旁腺功能亢进，可能是由于磷负荷或肠道钙吸收减少所致。
