Revenäs B, Smedegärd G, Saldeen T, Fredholm B B, Strandberg K
Acta Physiol Scand. 1981 Mar;111(3):249-57. doi: 10.1111/j.1748-1716.1981.tb06733.x.
Seven monkeys were passively sensitized intravenously (i.v.) with human serum containing IgE antibodies specific to dog albumin. I.v. administration of the antigen resulted in an immediate increase in pulmonary resistance (Rpulm) with a concomitant decrease in pulmonary dynamic compliance (Cdyn). Initially these changes in the respiratory system resulted in pronounced effects on venous admixture, arterial oxygen saturation (SaO2) and arterial pH. After 30 min, as Rpulm and Cdyn returned towards control levels, the blood gas changes were mainly due to low cardiac output. There was a transient increase in hematocrit, a decrease in plasma fibrinogen and a transient reduction in the number of circulating leukocytes. The anaphylactic reaction resulted in a 10- to 30-fold increase in plasma adrenaline with time and in a substantial but less marked increase in plasma noradrenaline and dopamine. Probably as a consequence of the increase in plasma catecholamine, there was a rise in plasma cyclic AMP, glucose and glycerol. No increase in plasma histamine levels was found. In two animals sensitized with purified IgE a reaction which was less severe but had the same general pattern was observed. The findings show that IgE-mediated anaphylaxis in the monkey results in a bronchoconstriction leading to a profound respiratory disturbance characterized by decreased SaO2 due to increased venous admixture. After 30 min these variables were normalized and the shock state was dominated by poor tissue perfusion due to a low cardiac output.
七只猴子通过静脉内（i.v.）注射含有针对犬白蛋白的IgE抗体的人血清进行被动致敏。静脉注射抗原导致肺阻力（Rpulm）立即增加，同时肺动态顺应性（Cdyn）降低。最初，呼吸系统的这些变化对静脉混合、动脉血氧饱和度（SaO2）和动脉pH产生了显著影响。30分钟后，随着Rpulm和Cdyn恢复到对照水平，血气变化主要是由于心输出量降低。血细胞比容短暂增加，血浆纤维蛋白原减少，循环白细胞数量短暂减少。过敏反应导致血浆肾上腺素随时间增加10至30倍，血浆去甲肾上腺素和多巴胺也有显著但不太明显的增加。可能由于血浆儿茶酚胺增加，血浆环磷酸腺苷、葡萄糖和甘油升高。未发现血浆组胺水平升高。在用纯化IgE致敏的两只动物中，观察到反应较轻但总体模式相同的情况。研究结果表明，猴子中IgE介导的过敏反应导致支气管收缩，进而导致严重的呼吸紊乱，其特征是由于静脉混合增加导致SaO2降低。30分钟后，这些变量恢复正常，休克状态主要由心输出量低导致的组织灌注不良所主导。
