Hodgkin B C, Nelson C V, Angelakos E T
Am J Physiol. 1981 Oct;241(4):H541-6. doi: 10.1152/ajpheart.1981.241.4.H541.
The cardiac electrical resultant dipole moment (RDM) of 17 spontaneously hypertensive rats (SHR) was compared with that of 17 Wistar-Kyoto rats (WKY), 65-100 days of age. Relative to body weight, left ventricular weight was 23% greater and right ventricular weight was 18% greater for SHR than for WKY. Left ventricular wall thickness was 11% larger and myocyte diameter was 13% larger for SHR than for WKY. RDM orientation for SHR was more dorsal, leftward, and cranial from middle to end of qRS. The second spatial magnitude peak of QRS, M2, was significantly smaller for SHR than for WKY (P less than 0.001) whereas M3 for SHR was significantly greater than for WKY (P less than 0.001). The alterations in RDM of SHR are greater than can be accounted for simply on the basis of increased cell size. The excitation sequence for SHR might be different from that of WKY. Results show the necessity of considering the details of the spatial magnitude curve during QRS.
对17只65至100日龄的自发性高血压大鼠（SHR）和17只Wistar-Kyoto大鼠（WKY）的心脏电综合偶极矩（RDM）进行了比较。相对于体重，SHR的左心室重量比WKY大23%，右心室重量比WKY大18%。SHR的左心室壁厚度比WKY大11%，心肌细胞直径比WKY大13%。从qRS的中间到末尾，SHR的RDM方向更靠后、向左且更靠近头端。SHR的QRS波群的第二个空间幅值峰值M2明显小于WKY（P<0.001），而SHR的M3明显大于WKY（P<0.001）。SHR的RDM变化大于仅基于细胞大小增加所能解释的范围。SHR的兴奋顺序可能与WKY不同。结果表明，在QRS波群期间考虑空间幅值曲线的细节是必要的。
