Atanasiu P, Perrin P, Segre L, Manganas O
Arch Inst Pasteur Tunis. 1981 Sep-Dec;58(3):401-21.
Homologous or heterologous diploid or polyploid cells have been established as good producers of virus. In this study we present three types of experimental inactivated antirabies vaccines obtained under identical conditions from three types of cells. The study concerns the following characteristics of the vaccines: protecting powers, rabies antigens and major polypeptidic components; this study was performed on supernatants of tissue cultures and concentrated and purified vaccines. Moreover, some cellular and serum contaminants as well as minor rabies proteins were analysed in the viral solutions. It, thus, appears that all these types of vaccines have a similar protecting power (Number of 50% protective doses/micrograms viral protein).
同源或异源二倍体或多倍体细胞已被确认为良好的病毒生产细胞。在本研究中，我们展示了在相同条件下从三种类型的细胞中获得的三种实验性灭活抗狂犬病疫苗。该研究涉及疫苗的以下特性：保护力、狂犬病抗原和主要多肽成分；这项研究是在组织培养上清液以及浓缩和纯化疫苗上进行的。此外，还对病毒溶液中的一些细胞和血清污染物以及少量狂犬病蛋白进行了分析。因此，似乎所有这些类型的疫苗都具有相似的保护力（50%保护剂量/微克病毒蛋白的数量）。
