Evaluation and comparative studies of inactivated rabies vaccines obtained in the heterologous diploid and polyploid cells (HAK, BHK and VERO).

This study is concerned with the following characteristics of the vaccines: 1.) protecting power, 2.) rabies antigens and 3.) major polypeptide components. This study was performed on supernatants of tissue cultures and on concentrated and purified vaccines. Moreover, some cellular and serum contaminants, especially the proteins produced by BHK cells, as well as minor rabies proteins, were analysed in the viral solutions. Thus, it appears that all three types of vaccines have a similar protecting power (Number of 50% protective doses/micrograms viral protein).