Karcioglu Z, Someren A, Mathes S J
Cancer. 1977 Jun;39(6):2486-96. doi: 10.1002/1097-0142(197706)39:6<2486::aid-cncr2820390627>3.0.co;2-e.
A case is reported in which a tumor containing elements of mature and immature ganglioneuroma, Schwannoma, clusters of apparently benign melanocytes and embryonal rhabdomyosarcoma presented as a right-sided facial mass in a six-month-old child. Different elements of the tumor were intimately intermingled without distinct borders. Embryogenesis of the tumor, which is thought to arise from remnants of migratory neural crest cells (ectomesenchyme), showing multidirectional phenotypic expression is discussed. It was felt that the lesion contributed additional evidence in support of pluripotentiality of the migratory, neural crest derivatives, and their susceptibility to mutagenic and oncogenic influences.
报道了一例病例，一名6个月大儿童右侧面部出现肿块，肿瘤包含成熟和未成熟神经节神经瘤、神经鞘瘤、明显良性黑素细胞簇以及胚胎性横纹肌肉瘤成分。肿瘤的不同成分紧密混合，无明显边界。讨论了该肿瘤的胚胎发生，其被认为起源于迁移的神经嵴细胞（外胚间叶组织）的残余物，表现出多向性表型表达。认为该病变为迁移的神经嵴衍生物的多能性及其对诱变和致癌影响的易感性提供了更多证据。
