Shideler C E, Johns M E, Cantrell R W, Shipe J R, Wills M R, Savory J
Arch Otolaryngol. 1981 Dec;107(12):752-4. doi: 10.1001/archotol.1981.00790480028007.
Erythrocyte polyamine levels were measured in the blood from 29 untreated patients whose conditions were diagnosed as head and neck cancer. Only nine (31%) of these patients had elevations of erythrocyte spermidine and/or spermine levels above the reference ranges determined for normal persons. However, a positive correlation was observed between the erythrocyte spermidine levels and the clinical tumor stage. Serial erythrocyte polyamine determinations were performed on the blood from 12 of these patients before and after either surgical or radiation therapy. In 11 of the cases, the erythrocyte spermidine levels decreased after tumor therapy regardless of whether there was prior elevation above the reference range. The erythrocyte spermine levels in these patients were more variable in their response to tumor treatment. Therefore, although erythrocyte polyamine levels were only slightly to moderately elevated in response to the small tumors characteristic of the head and neck, the measurement of erythrocyte spermidine, potentially, may offer a simple and effective means of monitoring the course of therapy used in patients with head and neck cancer.
对29名未经治疗、被诊断为头颈癌的患者的血液进行了红细胞多胺水平检测。这些患者中只有9名（31%）的红细胞亚精胺和/或精胺水平高于为正常人确定的参考范围。然而，观察到红细胞亚精胺水平与临床肿瘤分期之间存在正相关。对其中12名患者在手术或放疗前后的血液进行了连续红细胞多胺测定。在11例病例中，无论之前是否高于参考范围，肿瘤治疗后红细胞亚精胺水平均下降。这些患者的红细胞精胺水平对肿瘤治疗的反应更具变异性。因此，尽管对头颈癌特有的小肿瘤，红细胞多胺水平仅轻微至中度升高，但红细胞亚精胺的检测可能为监测头颈癌患者的治疗过程提供一种简单有效的方法。
