Cipolla B, Guillé F, Moulinoux J P, Quemener V, Staerman F, Corbel L, Lobel B
Service d'Urologie, Centre Hospitalier Universitaire de Rennes, France.
Eur Urol. 1993;24(1):124-31. doi: 10.1159/000474279.
The erythrocyte polyamines, spermidine and spermine, are known proliferation markers. The authors present their experience with polyamines and prostatic carcinoma. 229 patients with prostatic carcinoma had polyamine erythrocyte determination at diagnosis. Previous results confirmed a tendency to spermidine increase with tumor stage and a significant increase in spermine in metastatic and hormonal escape patients. No correlation was found between polyamine erythrocyte levels and hemoglobin, prostate-specific antigen or tumor grade. 148 prostatic carcinoma patients were followed up. Their pretreatment erythrocyte polyamine levels were correlated to progression. Patients (whatever stage) with rapid progression present significantly enhanced pretreatment erythrocyte spermine levels compared to patients with a favorable outcome. Polyamines are not only proliferation markers but are also necessary for cell division. The authors present their results on polyamine deprivation, combining a polyamine-free diet, polyamine synthesis inhibitors and intestinal tract decontamination, on in vivo tumor growth inhibition of the murine prostatic carcinoma Dunning Mat LyLu tumor model.
红细胞多胺（亚精胺和精胺）是已知的增殖标志物。作者介绍了他们在多胺与前列腺癌方面的经验。229例前列腺癌患者在诊断时进行了红细胞多胺测定。先前的结果证实，随着肿瘤分期的增加，亚精胺有升高趋势，而在发生转移和激素抵抗的患者中精胺显著增加。未发现红细胞多胺水平与血红蛋白、前列腺特异性抗原或肿瘤分级之间存在相关性。对148例前列腺癌患者进行了随访。他们治疗前的红细胞多胺水平与病情进展相关。与预后良好的患者相比，病情快速进展的患者（无论处于何分期）治疗前的红细胞精胺水平显著升高。多胺不仅是增殖标志物，而且是细胞分裂所必需的。作者介绍了他们在多胺剥夺方面的结果，即将无多胺饮食、多胺合成抑制剂和肠道去污相结合，对小鼠前列腺癌邓宁Mat LyLu肿瘤模型的体内肿瘤生长抑制作用。
