与镰状细胞-血红蛋白C病增殖性视网膜病变相关的血液学因素。
Haematological factors associated with proliferative retinopathy in sickle cell-haemoglobin C disease.
作者信息
Hayes R J, Condon P I, Serjeant G R
出版信息
Br J Ophthalmol. 1981 Oct;65(10):712-7. doi: 10.1136/bjo.65.10.712.
Abstract
In a selected sample of patients with sickle cell-haemoglobin C (SC) disease, proliferative retinopathy (PSR) occurred in 90/243 (37%) patients, developed most frequently between the ages of 20 and 30 years, and affected 68% patients aged 45 years or over. Comparison of haematological indices in patients with and without PSR, after age-related effects were allowed for, indicated significant relationships with high mean cell volume in males and with low fetal haemoglobin in both sexes. A highly significant relationship with total haemoglobin level in males (as previously reported in SS disease) was shown in SC disease to be entirely secondary to a strong age-related trend in haemoglobin level.
摘要
在一组选定的镰状细胞-血红蛋白C（SC）病患者样本中，90/243（37%）例患者发生了增殖性视网膜病变（PSR），最常发生在20至30岁之间，45岁及以上患者中有68%受到影响。在考虑年龄相关影响后，对有和无PSR患者的血液学指标进行比较，结果表明，男性患者的平均细胞体积高以及男女两性的胎儿血红蛋白低与之存在显著关系。在SC病中，男性患者的总血红蛋白水平与之存在高度显著关系（如先前在SS病中所报道），结果显示这完全是由于血红蛋白水平存在强烈的年龄相关趋势所致。
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