与纯合子镰状细胞病增殖性视网膜病变相关的血液学因素。
Haematological factors associated with proliferative retinopathy in homozygous sickle cell disease.
作者信息
Hayes R J, Condon P I, Serjeant G R
出版信息
Br J Ophthalmol. 1981 Jan;65(1):29-35. doi: 10.1136/bjo.65.1.29.
Abstract
Haematological indices were investigated in 261 patients with homozygous sickle cell disease, 29 of whom had developed proliferative sickle retinopathy (PSR). After allowing for age-related effects, male patients with high Hb (> 9 g/dl) and low HbF (< 5%) levels appeared to constitute a high risk group for PSR. This relationship was not evident in females, PSR being observed in patients with lower Hb and higher HbF levels than in the male group. PSR occurred in 14% of patients aged 40 years or over in this sample.
摘要
对261例纯合子镰状细胞病患者的血液学指标进行了研究，其中29例已发生增殖性镰状视网膜病变（PSR）。在考虑年龄相关影响后，血红蛋白（Hb）水平高（>9 g/dl）且胎儿血红蛋白（HbF）水平低（<5%）的男性患者似乎构成PSR的高危组。这种关系在女性中不明显，女性组中发生PSR的患者Hb水平较低而HbF水平较高。在该样本中，40岁及以上患者中有14%发生了PSR。
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