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[叙利亚仓鼠在正常条件下及其对肿瘤的天然抵抗力受到抑制期间腹膜渗出细胞的迁移活性]

[Migration activity of peritoneal exudate cells in Syrian hamsters in normal conditions and during suppression of their natural resistance to tumors].

作者信息

Kashkina L M, Lavnikova N A

出版信息

Biull Eksp Biol Med. 1984 Mar;97(3):334-6.

PMID:6704526
Abstract

Migration activity (MA) of peritoneal exudate cells (PEC) was studied in Syrian hamsters in normalcy and under intraperitoneal injection into the animals of inactivated normal and tumor cells including those capable of inhibiting the natural animals' resistance to tumor. No significant individual differences were found in MA of PEC of intact hamsters. MA of PEC of hamsters treated with inactivated normal or spontaneously transformed in vitro cells of hamster embryo did not differ from the means of MA in the control. MA of PEC of hamsters treated with inactivated tumor cells was found to be appreciably enhanced. The ability of inactivated tumor cells to induce the enhancement of MA of PEC correlates with their ability to suppress natural tumor resistance.

摘要

在叙利亚仓鼠中,研究了正常情况下以及给动物腹腔注射灭活的正常细胞和肿瘤细胞(包括那些能够抑制动物对肿瘤的天然抵抗力的细胞)后腹膜渗出细胞(PEC)的迁移活性(MA)。未发现完整仓鼠PEC的MA存在显著个体差异。用灭活的正常仓鼠胚胎细胞或体外自发转化的仓鼠胚胎细胞处理的仓鼠PEC的MA与对照组的MA平均值无差异。发现用灭活肿瘤细胞处理的仓鼠PEC的MA明显增强。灭活肿瘤细胞诱导PEC的MA增强的能力与其抑制天然肿瘤抵抗力的能力相关。

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