Janeway C A, Murgita R A, Weinbaum F I, Asofsky R, Wigzell H
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4582-6. doi: 10.1073/pnas.74.10.4582.
Evidence from various systems suggests that thymus-derived lymphocytes can affect the quality of antibody responses by recognizing various portions of the immunoglobulin receptor of bone-marrow-derived thymus-independent lymphocytes. A model for this process is proposed involving two antigen-specific mature T helper cells, one of which also is specific for immunoglobulin determinants. These two cells act synergistically. Evidence from adoptive secondary antibody responses demonstrates that both cells are antigen-specific T cells and that the immunoglobulin-recognizing T helper cell is absent from experimentally agammaglobulinemic mice. This cell is termed an "immunoglobulin-dependent T cell" because its activation requires the presence of immunoglobulin.
来自多个系统的证据表明,胸腺来源的淋巴细胞可通过识别骨髓来源的非胸腺依赖性淋巴细胞免疫球蛋白受体的不同部分,来影响抗体反应的质量。本文提出了一个关于此过程的模型,该模型涉及两种抗原特异性成熟T辅助细胞,其中一种细胞也对免疫球蛋白决定簇具有特异性。这两种细胞协同发挥作用。过继性二次抗体反应的证据表明,这两种细胞均为抗原特异性T细胞,且在实验性无丙种球蛋白血症小鼠中不存在识别免疫球蛋白的T辅助细胞。这种细胞被称为“免疫球蛋白依赖性T细胞”,因为其激活需要免疫球蛋白的存在。