de Jager A E, The T H, Smit Sibinga C T, Das P C
Int J Artif Organs. 1981 Sep;4(5):230-3.
During the last 3 years plasma exchanges were undertaken in 5 patients with acute Guillain Barré syndrome (G.B.S.). All the patients were admitted in the intensive respiratory care unit and had received six plasma exchange procedures over two weeks (each procedure consists of 2-3 L exchange). The first patient improved dramatically after the second exchange. Moderate success was obtained in two patients. One patient did not show any effect. The fifth patient received plasma exchange one day after her recovery phase had begun but the course of recovery remained uneffected. The effect of plasma exchange was analysed as the patients' response to motor activity, and compared with a historical control group consisting of 50 acute G.B.S. patients admitted in the intensive respiratory care area over the last 25 years. Plasma exchange does not seem to have exerted any significant effect although at any given time the plasma exchange group had higher motor activity than that of the control group. A controlled clinical trial especially in the early phase of the disease is emphasized.
在过去3年里，对5例急性吉兰-巴雷综合征（G.B.S.）患者进行了血浆置换。所有患者均入住重症呼吸监护病房，并在两周内接受了6次血浆置换（每次置换量为2 - 3升）。第一名患者在第二次置换后显著好转。两名患者取得了中等程度的成功。一名患者未显示出任何效果。第五名患者在恢复期开始一天后接受了血浆置换，但恢复过程未受影响。通过患者对运动活动的反应来分析血浆置换的效果，并与过去25年入住重症呼吸监护区的50例急性G.B.S.患者组成的历史对照组进行比较。尽管在任何给定时间血浆置换组的运动活动都高于对照组，但血浆置换似乎并未产生任何显著效果。强调了进行对照临床试验，尤其是在疾病早期阶段。
