[Disturbance of the intracellular calcium distribution in the fatty tissue of rats with spontaneous genetic hypertension].

The presence of three pools of exchangeable calcium (A,B and C) was demonstrated by the method of investigating the kinetics of 45Ca efflux from the fat issue of rats; the two most slowly exchangeable pools (B and C) reflected the distribution of intracellular calcium. The calcium content in the pools B and C of the fat tissue of rats with spontaneous hypertension was increased by 71 and 29%, respectively, as compared to that in the normotensive controls. Adrenalectomy leads to a marked redistribution of intracellular calcium, but the differences between spontaneously hypertensive rats and normotensive rats in the calcium content in the pools B and C are nonetheless maintained. These differences in the distribution of intracellular calcium may be the direct cause of the change in the hormonal sensitivity of the adipocytes of rats with spontaneous genetic hypertension.