Orlov S N, Pokudin N I
Pflugers Arch. 1981 Jun;390(3):256-9. doi: 10.1007/BF00658271.
The intracellular calcium pool of adipose tissue was estimated by studying the kinetics of 45Ca efflux from the tissue of 9-week old spontaneously hypertensive (SHR) and normotensive Kyoto-Wistar (NKWR) rats subjected to peripheral immunosympathectomy (nerve growth factor antiserum treatment of newborn rats) and in intact (sham-treated) animals of both strains. The development of hypertension in SHR was prevented by immunosympathectomy, however, both groups, SHR-intact and immunosympathectomized rats showed an increase in the intracellular calcium content of adipocytes. These results indicate that the alteration of the membrane control over intracellular calcium distribution in adipose tissue of SHR cannot be attributed to an enhanced activity of the sympathetic nervous system.
通过研究9周龄自发性高血压（SHR）大鼠和正常血压京都-威斯塔大鼠（NKWR）的外周免疫交感神经切除术（新生大鼠的神经生长因子抗血清治疗）组织以及两品系完整（假手术处理）动物组织中45Ca流出动力学，来估计脂肪组织的细胞内钙库。免疫交感神经切除术可预防SHR高血压的发展，然而，SHR完整组和免疫交感神经切除组大鼠的脂肪细胞内钙含量均增加。这些结果表明，SHR脂肪组织中细胞膜对细胞内钙分布控制的改变不能归因于交感神经系统活性增强。
