Asmussen G, Gaunitz U
Pflugers Arch. 1981 Dec;392(2):198-205. doi: 10.1007/BF00581272.
The inferior oblique muscle (IO) of the rabbit was denervated. The mechanical properties of the muscles were determined at 35 degrees C in vitro 2--76 days after the operation. After denervation the muscles exhibited a considerable hypertrophy. The cross-sectional area of muscles denervated 30 days or longer grew to about twice as innervated controls. The length-tension relationship of passive or activated long-term denervated IO differed from normal in a higher stiffness. After denervation the time parameters of single twitches and tetanic contractions evoked by massive stimulation were prolonged, the fusion frequency was decreased, and the fatigue resistance was increased. During the first week after cutting the motor nerve both twitch and tetanic tensions decreased drastically. A minimum was reached at the end of the second weak. In the subsequent weeks the tension development was increased again, but per unit cross-sectional area it was always smaller than in innervated muscles. After denervation the twitch:tetanus ratio was increased. Cooling to 25 degrees C was followed by an increase in time parameters of single twitches and tetanic contractions and by a depression of twitch and tetanic tensions. Following a repetitive stimulation denervated IO showed a posttetanic depression of the single twitch.
对家兔的下斜肌进行去神经支配。在术后2至76天，于35摄氏度的体外环境中测定肌肉的力学特性。去神经支配后，肌肉出现明显肥大。去神经支配30天或更长时间的肌肉横截面积增长至约为有神经支配对照组的两倍。被动或激活的长期去神经支配下斜肌的长度-张力关系与正常情况不同，其刚度更高。去神经支配后，大量刺激诱发的单收缩和强直收缩的时间参数延长，融合频率降低，抗疲劳能力增强。切断运动神经后的第一周，单收缩和强直张力均急剧下降。在第二周结束时达到最小值。在随后的几周中，张力发展再次增加，但每单位横截面积的张力始终小于有神经支配的肌肉。去神经支配后，单收缩与强直收缩的比值增加。冷却至25摄氏度后，单收缩和强直收缩的时间参数增加，单收缩和强直张力降低。重复刺激后，去神经支配的下斜肌出现单收缩的强直后抑制。
