Hennig C W, Steinhoff W C, Braughler S A
Psychology Department, Salem College, WV 26426.
Physiol Behav. 1988;44(1):15-20. doi: 10.1016/0031-9384(88)90340-x.
Low doses of serotonin potentiated immobility durations in 2 1/2-week-old chickens (Gallus gallus) while high doses attenuated the response. Cyproheptadine, a serotonergic antagonist, eliminated increases generated by low doses of serotonin and reduced durations in control subjects, but had no effect on the attenuation produced by high doses of the drug. Cinanserin, another serotonergic blocker, also eliminated the potentiation generated by low doses of serotonin and partially reduced the attenuation caused by high doses, but had no effect on immobility durations in control animals. Larger doses of cinanserin eliminated the attenuation produced by high doses of serotonin and increased durations in control subjects. Results are discussed in terms of the differential blockade of various serotonin receptors.
低剂量血清素增强了2.5周龄小鸡（原鸡）的静止时间，而高剂量则减弱了这种反应。血清素拮抗剂赛庚啶消除了低剂量血清素产生的增加，并缩短了对照实验对象的静止时间，但对高剂量药物产生的减弱作用没有影响。另一种血清素阻滞剂辛那色林也消除了低剂量血清素产生的增强作用，并部分减轻了高剂量血清素引起的减弱作用，但对对照动物的静止时间没有影响。更大剂量的辛那色林消除了高剂量血清素产生的减弱作用，并增加了对照实验对象的静止时间。根据对各种血清素受体的不同阻断作用对结果进行了讨论。
